17

Dooku1

17 Publications Verification

Cat. No.: HY-126010

CAS No.: 2253744-54-4

Purity: 99.93%

Target:

Piezo Channel

Research Areas:

Others

Dooku1 is a reversibly Yoda1 antagonist with IC₅₀ value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca ²⁺ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research .

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12

DMEM (High Glucose, L-Glutamine, Pyruvate, Phenol Red, no HEPES)

12 Cited Publications

Cat. No.: HY-K3001

DMEM (Dulbecco's Modified Eagle Medium) is a widely used basal medium for supporting the growth of many different mammalian cells. Cell lines successfully cultured in DMEM include Hela, 293, Cos-7, and PC-12, as well as primary fibroblasts, neurons, glial cells, HUVECs, and smooth muscle cells. The 500 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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5

Isosorbide mononitrate

5 Cited Publications

Cat. No.: HY-B0642

CAS No.: 16051-77-7

Synonyms: Isosorbide-5-mononitrate

Category:

Cardiovascular Disease Disease Research Fields Cancer

Target:

Autophagy Apoptosis

Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease .

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3

SAR247799

3 Cited Publications

Cat. No.: HY-115831

CAS No.: 1315311-14-8

Purity: 99.38%

Synonyms: S1P1 agonist 3

Target:

LPL Receptor

Research Areas:

Cardiovascular Disease

SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC₅₀s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome .

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3

Ascorbyl palmitate

3 Cited Publications

Cat. No.: HY-B0987

CAS No.: 137-66-6

Synonyms: L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid

Category:

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

Environmental Pollutants Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Bcl-2 Family Caspase Calcium Channel NOD-like Receptor (NLR) Sodium Channel

Ascorbyl palmitate is an orally active ester formed from ascorbic acid and palmitic acid, used as an antioxidant and food additive. Ascorbyl palmitate in preventing fat and oil oxidation is more efficient than Butylated hydroxyanisole (HY-B1066) and Butylated hydroxytoluene (HY-Y0172). Ascorbyl palmitate mitigates inhibition of collagen synthesis by select calcium and sodium channel blockers. Ascorbyl palmitate induces Apoptosis in human umbilical vein endothelial cells (HUVECs). Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome .

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3

Volociximab

3 Cited Publications

Cat. No.: HY-P99333

CAS No.: 558480-40-3

Synonyms: M200; Eos 200-4

Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1 (EC₅₀=0.2 nM). Integrin α5β1 is a major fibronectin receptor involved in angiogenesis. Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs) .

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3

Abietic acid

3 Cited Publications

Cat. No.: HY-N6871

CAS No.: 514-10-3

Category:

Infection Colophony Ketones, Aldehydes, Acids Metabolic Disease Plants Pinaceae Extract Disease Research Fields Inflammation/Immunology

Target:

Bacterial IKK Ferroptosis

Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .

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