48 Results for "

Hemolysis

" in MedChemExpress (MCE) Product Catalog:
Products (48)

48 Results for "Hemolysis" in MCE Product Catalog:

14
Iptacopan
Iptacopan
0 Images
14 Publications Verification
Cat. No.: HY-127105
CAS No.: 1644670-37-0
Purity:  99.93%
Synonyms: LNP023
Target:  

Complement System

Research Areas:  

Metabolic Disease Inflammation/Immunology

Iptacopan (LNP023) is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
loading...
    loading...
View All Sizes
14
Iptacopan hydrochloride
Iptacopan hydrochloride
0 Images
14 Publications Verification
Cat. No.: HY-127105A
CAS No.: 1646321-63-2
Purity:  99.83%
Synonyms: LNP023 hydrochloride
Target:  

Complement System

Research Areas:  

Metabolic Disease Inflammation/Immunology

Iptacopan (LNP023) hydrochloride is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
loading...
    loading...
View All Sizes
11
Cardiotoxin Analog (CTX) IV (6-12)
Cardiotoxin Analog (CTX) IV (6-12)
0 Images
11 Cited Publications
Cat. No.: HY-P1902
CAS No.: 115722-23-1
Category:  

Cardiovascular Disease Natural Products Animals Disease Research Fields

Target:  

Apoptosis

Cardiotoxin Analog (CTX) IV (6-12) is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .
loading...
    loading...
View All Sizes
11
G6PD activator AG1
G6PD activator AG1
0 Images
11 Cited Publications
Cat. No.: HY-123962
CAS No.: 421581-52-4
Purity:  98.18%
Target:  

NADPH Oxidase

Research Areas:  

Metabolic Disease

G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes .
loading...
    loading...
View All Sizes
11
Cardiotoxin Analog (CTX) IV (6-12) TFA
Cardiotoxin Analog (CTX) IV (6-12) TFA
0 Images
11 Cited Publications
Cat. No.: HY-P1902A
CAS No.: 2918768-05-3
Category:  

Pyrrole Alkaloids Animals Other Diseases Disease Research Fields

Target:  

Apoptosis

Cardiotoxin Analog (CTX) IV (6-12) TFA is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) TFA was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) TFA is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) TFA can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .
loading...
    loading...
View All Sizes
7
Quinine (hydrochloride)
Quinine (hydrochloride)
0 Images
7 Cited Publications
Cat. No.: HY-110082
CAS No.: 130-89-2
Target:  

Flavivirus Dengue Virus Parasite Potassium Channel

Research Areas:  

Cardiovascular Disease Infection Cancer

Quinine hydrochloride is an alkaloid extracted from cinchona bark and exhibits oral activity, acting as a potassium channel inhibitor. Quinine hydrochloride modulates the tolerance of red blood cells and presents dose-dependent toxicity and embryonic effects. Quinine hydrochloride is a typical hemolysin that directly lyses red blood cells, with cellular components of red blood cell membranes as its action targets. Quinine hydrochloride disrupts red blood cell membranes and induces hemolysis at high concentrations, while merely weakening the anti-hemolytic capacity of red blood cells at low concentrations. Quinine hydrochloride continuously reduces red blood cell tolerance after in vivo administration, and high doses can also alter blood cell counts. Quinine hydrochloride can be applied to researches related to red blood cell hemolysis, cancer and malaria .
loading...
    loading...
View All Sizes
4
Eculizumab
Eculizumab
0 Images
4 Cited Publications
Cat. No.: HY-P9914
CAS No.: 219685-50-4
Synonyms: Anti-Human C5, Humanized Antibody; h5G1.1

Target:  

Complement System

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology

Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice. Eculizumab can be used in hemolysis studies .
loading...
    loading...
View All Sizes
3
AAPH
AAPH
0 Images
3 Cited Publications
Cat. No.: HY-Y0525
CAS No.: 2997-92-4
Synonyms: 2,2'-Azodiisobutyramidine dihydrochloride
Target:  

Reactive Oxygen Species (ROS)

Research Areas:  

Inflammation/Immunology

AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis . AAPH decomposes at 37°C to generate an alkyl radical, is used as an initiator. In the presence of oxygen, these alkyl radicals will be converted to peroxyl radicals that can cause lipid peroxidation and loss of erythrocyte membrane integrity, which could ultimately lead to hemolysis .
loading...
    loading...
View All Sizes
1
Polyporusterone B
Polyporusterone B
0 Images
1 Cited Publications
Cat. No.: HY-N7693
CAS No.: 141360-89-6
Category:  

Other Diseases Polyporaceae Extract 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.