3

(Rac)-SHIN2

3 Cited Publications

Cat. No.: HY-134978

CAS No.: 2204289-53-0

Purity: 99.40%

Target:

SHMT Bacterial

Research Areas:

Others

(Rac)-SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac)-SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac)-SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus ^[2].

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1

Omidenepag

1 Cited Publications

Cat. No.: HY-17642

CAS No.: 1187451-41-7

Synonyms: UR-7276

Target:

Prostaglandin Receptor

Research Areas:

Endocrinology

Omidenepag (UR-7276), a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC₅₀ of 1.1 nM. Omidenepag shows binding affinities (IC₅₀) 10 nM for h-EP2. Omidenepag is used in research on diseases related to intraocular pressure ^[2].

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1

Leucomalachite green

1 Cited Publications

Cat. No.: HY-D0300

CAS No.: 129-73-7

Leucomalachite green is the major reduced metabolite of malachite green (MG) and has lower cytotoxicity (such as HEp-2 and Caco-2) than malachite green. Leucomalachite green may be involved in interfering with cell metabolism or redox balance and can be used to evaluate its potential harm to human cells as a food contaminant ^[2].

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1

RSV L-protein-IN-1

1 Cited Publications

Cat. No.: HY-115574

CAS No.: 851658-10-1

Purity: 98.09%

Target:

RSV

Research Areas:

Infection

RSV L-protein-IN-1 (compound D) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC₅₀=0.021 μM). RSV L-protein-IN-1 inhibits Polymerase (IC₅₀=0.089 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-1 shows moderate cytotoxicity (CC50=8.4 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection .

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Basic green 4

Cat. No.: HY-D0203

CAS No.: 569-64-2

Synonyms: Malachite green

Basic green 4 (Malachite green) is a cationic dye that is widely used as a bactericide in aquaculture and is also commonly used in laboratories for the determination of phosphates. Basic green 4 exhibits high cytotoxicity and carcinogenicity to mammalian cells, specifically shown by its IC₅₀ values of 2.03 µM for HEp-2 human laryngeal cells and 13.8 µM for Caco-2 human colorectal adenocarcinoma cells, and it can promote the development of liver tumors. The maximum absorbance wavelength is 621 nm ^[2] .

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EP2 receptor antagonist-3

Cat. No.: HY-176293

CAS No.: 1799626-16-6

Target:

Prostaglandin Receptor Amyloid-β

Research Areas:

Neurological Disease

EP2 receptor antagonist-3 is a selective EP2 receptor antagonist (IC₅₀: 8 nM in hEP2 SPA assay, 50 nM in hEP2 cAMP assay). EP2 receptor antagonist-3 increases the macrophage-mediated clearance of Amyloid-β plaques. EP2 receptor antagonist-3 can be used for the study of alzheimer’s diseases .

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Setipiprant

Cat. No.: HY-16635

CAS No.: 866460-33-5

Synonyms: ACT-129968; KYTH-105

Target:

Prostaglandin Receptor

Research Areas:

Inflammation/Immunology Endocrinology

Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist. Setipiprant interacts with hCRTH2 receptor with an IC₅₀ value of 6 nM. Setipiprant inhibits prostanoid receptors hDP₁ and hEP₂ with IC₅₀ values of 1290 and 2600 nM, respectively. Setipiprant can be used for the research of asthma and rhinitis .

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TG8-260

Cat. No.: HY-164049

CAS No.: 2490544-50-6

Target:

Prostaglandin Receptor

Research Areas:

Inflammation/Immunology

TG8-260 is a second-generation EP2 antagonist developed to alleviate the pathology of central nervous system and peripheral diseases driven by inflammation. TG8-260 can reduce neuroinflammation and gliosis in the hippocampus of rats after pilocarpine-induced persistent epileptic status. Pharmacokinetic data of TG8-260 showed that its plasma half-life was 2.14 hours and its oral bioavailability was 77.3%. TG8-260 is also a potent inhibitor of CYP450 and shows antagonistic activity in inhibiting EP2 receptor-mediated inflammatory gene expression in BV2-hEP2 microglia, which is suitable for studying anti-inflammatory pathways in animal models of peripheral inflammatory diseases .

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