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23 Results for "

Hep3B Cells

" in MedChemExpress (MCE) Product Catalog:

Products (23)

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PROTAC PD-1/PD-L1 degrader-1

Cat. No.: HY-131183

CAS No.: 2447066-37-5

Purity: 99.52%

Target:

PROTACs PD-1/PD-L1

Research Areas:

Inflammation/Immunology

PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC₅₀ of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner .

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PAT-505

Cat. No.: HY-107781

CAS No.: 1782070-22-7

Purity: 98.84%

Target:

Phosphodiesterase (PDE)

Research Areas:

Inflammation/Immunology

PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC₅₀ of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma.

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LEB-03-146

Cat. No.: HY-144999

CAS No.: 2858812-91-4

Purity: 98.08%

Target:

DUBTACs Wee1

Research Areas:

Cancer

LEB-03-146 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a PEG2 linker. LEB-03-146 shows significant WEE1 stabilization in HEP3B hepatoma cancer cells .

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LEB-03-144

Cat. No.: HY-143342

CAS No.: 2858812-89-0

Target:

DUBTACs Wee1

Research Areas:

Cancer

LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant WEE1 stabilization in HEP3B hepatoma cancer cells .

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