161

161 Publications Verification

Purity: 99.23%

BAPTA-AM is a well-known membrane permeable Ca ²⁺ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC₅₀s of 1.3 μM, 1.45 μM and 1.23 μM, respectively .

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161

Chlorpromazine

161 Publications Verification

Cat. No.: HY-12708

CAS No.: 50-53-3

Purity: 99.75%

Target:

Dopamine Receptor Cytochrome P450 Autophagy 5-HT Receptor

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis .

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161

Chlorpromazine hydrochloride

161 Publications Verification

Cat. No.: HY-B0407A

CAS No.: 69-09-0

Target:

Dopamine Receptor Autophagy Cytochrome P450 5-HT Receptor

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .

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30

Rosuvastatin Calcium

30 Cited Publications

Cat. No.: HY-17504

CAS No.: 147098-20-2

Synonyms: Rosuvastatin hemicalcium; ZD 4522 Calcium

Target:

HMG-CoA Reductase (HMGCR) Autophagy Potassium Channel Bacterial

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC₅₀ of 195 nM . Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

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30

Rosuvastatin

30 Cited Publications

Cat. No.: HY-17504A

CAS No.: 287714-41-4

Synonyms: ZD 4522

Target:

HMG-CoA Reductase (HMGCR) Autophagy Potassium Channel Bacterial

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks hERG current with an IC₅₀ of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

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30

Rosuvastatin Sodium

30 Cited Publications

Cat. No.: HY-17504B

CAS No.: 147098-18-8

Synonyms: ZD 4522 Sodium; X-Plended Sodium; Crestor Sodium

Target:

HMG-CoA Reductase (HMGCR) Potassium Channel Autophagy Bacterial

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC₅₀ of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

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23

Clarithromycin

23 Cited Publications

Cat. No.: HY-17508

CAS No.: 81103-11-9

Target:

Bacterial Cytochrome P450 Autophagy Antibiotic

Research Areas:

Infection Cancer

Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC₅₀ (K_i) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .

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18

Ketanserin

18 Cited Publications

Cat. No.: HY-10562

CAS No.: 74050-98-9

Purity: 99.89%

Synonyms: R41468

Target:

5-HT Receptor Potassium Channel Autophagy

Research Areas:

Neurological Disease

Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current (I_hERG) in a concentration-dependent manner (IC₅₀=0.11 μM).

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18

Ketanserin tartrate

18 Cited Publications

Cat. No.: HY-10562A

CAS No.: 83846-83-7

Purity: 99.99%

Synonyms: R41468 tartrate

Target:

5-HT Receptor Potassium Channel Autophagy

Research Areas:

Neurological Disease

Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (I_hERG) in a concentration-dependent manner (IC₅₀=0.11 μM).

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18

Branaplam

18 Cited Publications

Cat. No.: HY-19620

CAS No.: 1562338-42-4

Synonyms: LMI070; NVS-SM1

Target:

DNA/RNA Synthesis Potassium Channel

Research Areas:

Cancer

Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model .

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18

Branaplam hydrochloride

18 Cited Publications

Cat. No.: HY-19620A

CAS No.: 1562338-39-9

Synonyms: LMI070 hydrochloride; NVS-SM1 hydrochloride

Target:

DNA/RNA Synthesis Potassium Channel

Research Areas:

Cancer

Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model .

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