1735 Results for "

High affinity

" in MedChemExpress (MCE) Product Catalog:
Products (1735)

1735 Results for "High affinity" in MCE Product Catalog:

333
Stattic
Stattic
0 Images
333 Publications Verification
Cat. No.: HY-13818
CAS No.: 19983-44-9
Purity:  99.58%
Target:  

STAT Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727) . Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3 . Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice .
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77
FPS-ZM1
FPS-ZM1
0 Images
77 Cited Publications
Cat. No.: HY-19370
CAS No.: 945714-67-0
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

FPS-ZM1 is a high-affinity and BBB-permeable RAGE inhibitor with a Ki of 25 nM.
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75
Trastuzumab
Trastuzumab
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75 Cited Publications
Cat. No.: HY-P9907
CAS No.: 180288-69-1
Synonyms: Anti-Human HER2, Humanized Antibody
Target:  

Radionuclide-Drug Conjugates (RDCs) EGFR ADC Antibodies

Research Areas:  

Cancer

Trastuzumab is a humanized IgG1 monoclonal antibody that selectively binds to HER2 with high affinity. Trastuzumab can be used for the research of HER2-positive metastatic breast cancer and gastric cancer . (Note: The product specifications below only indicate the effective content of Trastuzumab. The component ratio of this product is Trastuzumab : excipients = 1:0.6-1:0.9.)
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61
Tariquidar
Tariquidar
0 Images
61 Cited Publications
Cat. No.: HY-10550
CAS No.: 206873-63-4
Purity:  99.45%
Synonyms: XR9576
Target:  

P-glycoprotein

Research Areas:  

Cancer

Tariquidar (XR9576) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM) .
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61
GSK484 hydrochloride
GSK484 hydrochloride
0 Images
61 Cited Publications
Cat. No.: HY-100514
CAS No.: 1652591-81-5
Purity:  99.48%
Target:  

Protein Arginine Deiminase

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

GSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed.
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57
Pioglitazone
Pioglitazone
0 Images
57 Cited Publications
Cat. No.: HY-13956
CAS No.: 111025-46-8
Purity:  99.89%
Synonyms: U 72107
Target:  

PPAR Ferroptosis

Research Areas:  

Metabolic Disease Cancer

Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research .
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56
Calcipotriol
Calcipotriol
0 Images
56 Cited Publications
Cat. No.: HY-10001
CAS No.: 112965-21-6
Purity:  99.93%
Synonyms: MC 903; Calcipotriene
Target:  

VD/VDR

Research Areas:  

Inflammation/Immunology Cancer

Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
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56
Calcipotriol monohydrate
Calcipotriol monohydrate
0 Images
56 Cited Publications
Cat. No.: HY-10001A
CAS No.: 147657-22-5
Purity:  99.95%
Target:  

VD/VDR

Research Areas:  

Inflammation/Immunology Cancer

Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
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55
Propranolol hydrochloride
Propranolol hydrochloride
0 Images
55 Cited Publications
Cat. No.: HY-B0573
CAS No.: 318-98-9
Category:  

Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology

Target:  

Adrenergic Receptor Bacterial

Propranolol hydrochloride is a nonselective and BBB-permeableβ-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [ 3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .
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55
Propranolol
Propranolol
0 Images
55 Cited Publications
Cat. No.: HY-B0573B
CAS No.: 525-66-6
Category:  

Cardiovascular Disease Alkaloids Natural Products Neurological Disease Other Alkaloids Plants Aconitum carmichaeli Debx. Extract Disease Research Fields Ranunculaceae Extract

Target:  

Adrenergic Receptor Bacterial

Propranolol is a nonselective and BBB-permeable β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [ 3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .
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46
Rhod-2 AM
Rhod-2 AM
0 Images
46 Cited Publications
Cat. No.: HY-D0989
CAS No.: 145037-81-6
Rhod-2 is a high-affinity visible light excitation wavelength Ca 2+ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm .
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45
G15
G15
0 Images
45 Cited Publications
Cat. No.: HY-103449
CAS No.: 1161002-05-6
Purity:  ≥99.0%
Target:  

Estrogen Receptor/ERR

Research Areas:  

Cancer

G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM .
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44
2',3'-cGAMP
2',3'-cGAMP
0 Images
44 Cited Publications
Cat. No.: HY-100564
CAS No.: 1441190-66-4
Purity:  99.95%
Synonyms: 2'-3'-cyclic GMP-AMP
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite STING IFNAR

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm .
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44
2',3'-cGAMP sodium
2',3'-cGAMP sodium
0 Images
44 Cited Publications
Cat. No.: HY-100564A
CAS No.: 2734858-36-5
Purity:  99.63%
Synonyms: 2'-3'-cyclic GMP-AMP sodium
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite STING IFNAR

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm .
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43
ANA-12
ANA-12
0 Images
43 Cited Publications
Cat. No.: HY-12497
CAS No.: 219766-25-3
Purity:  99.90%
Target:  

Trk Receptor NOD-like Receptor (NLR) AIM2 Caspase

Research Areas:  

Neurological Disease Inflammation/Immunology

ANA-12 is a brain-penetrant, selective TrkB antagonist with IC50 values of 45.6 nM and 41.1 μM, and Kd values of 10 nM and 12 μM, for high- and low-affinity sites, respectively. ANA-12 specifically inhibits BDNF-induced TrkB receptor activation and its downstream signaling cascades by directly and non-competitively binding to the TrkB receptor, without affecting the functions of TrkA and TrkC. ANA-12 is used in research concerning neuropsychiatric disorders (such as depression and anxiety), acute and chronic pain, neuroimmune inflammation, and the mechanisms of learning and memory .
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39
MPP+ iodide
MPP+ iodide
0 Images
39 Cited Publications
Cat. No.: HY-W008719
CAS No.: 36913-39-0
Target:  

Mitochondrial Metabolism

Research Areas:  

Neurological Disease

MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .
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39
SCH-23390 hydrochloride
SCH-23390 hydrochloride
0 Images
39 Cited Publications
Cat. No.: HY-19545A
CAS No.: 125941-87-9
Synonyms: R-(+)-SCH-23390 hydrochloride
Target:  

Dopamine Receptor 5-HT Receptor Potassium Channel

Research Areas:  

Neurological Disease

SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM .
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38
Coppersensor 1
Coppersensor 1
0 Images
38 Cited Publications
Cat. No.: HY-141511
CAS No.: 874748-20-6
Purity:  97.74%
Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu + with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu +) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases .
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34
Evans Blue
Evans Blue
0 Images
34 Cited Publications
Cat. No.: HY-B1102
CAS No.: 314-13-6
Synonyms: Direct Blue 53; T-1824; C.I. 23860
Target:  

EAAT iGluR

Research Areas:  

Cardiovascular Disease Neurological Disease

Evans Blue (Direct Blue 53; T-1824; C.I. 23860) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability .
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31
Harmine hydrochloride
Harmine hydrochloride
0 Images
31 Cited Publications
Cat. No.: HY-N0737
CAS No.: 343-27-1
Synonyms: Telepathine hydrochloride
Category:  

Alkaloids Zygophyllaceae Extract 500 - Internal Server Error | MedChemExpress

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