31 Results for "

Hippo pathway

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "Hippo pathway" in MCE Product Catalog:

4
EMT inhibitor-1
EMT inhibitor-1
0 Images
4 Cited Publications
Cat. No.: HY-101275
CAS No.: 1638526-21-2
Purity:  99.45%
Target:  

Hippo (MST) TGF-beta/Smad Wnt

Research Areas:  

Cancer

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.
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2
SBP-3264
SBP-3264
0 Images
2 Cited Publications
Cat. No.: HY-132969
CAS No.: 2869148-13-8
Purity:  98.50%
Target:  

Hippo (MST) YAP

Research Areas:  

Cancer

SBP-3264 is a YAP activator and STK/MST inhibitor with IC50 values of 36 nM against STK3/MST2 and 24 nM against STK4/MST1. SBP-3264 modulates the Hippo signaling pathway. SBP-3264 can be used for the research of acute myeloid leukemia .
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VT02956
VT02956
0 Images
1 Cited Publications
Cat. No.: HY-147165
CAS No.: 2999763-09-4
Purity:  99.58%
Target:  

Ser/Thr Kinase Large Tumor Suppressor (LATS)

Research Areas:  

Cancer

VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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MY-875
MY-875
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1 Cited Publications
Cat. No.: HY-150761
Purity:  99.56%
Target:  

Microtubule/Tubulin Apoptosis

Research Areas:  

Cancer

MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity .
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VT3989
VT3989
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Cat. No.: HY-400902
CAS No.: 2506273-81-8
Target:  

YAP VEGFR Hippo (MST)

Research Areas:  

Cancer

VT3989 is an orally active pan-TEAD autopalmitoylation inhibitor that modulates the Hippo signaling pathway. VT3989 directly binds to TEAD transcription factors to block their palmitoylation modification, thereby disrupting the formation of YAP/TAZ-TEAD complexes and inhibiting downstream oncogenic transcriptional activity. VT3989 effectively inhibits the growth of NF2-deficient schwannoma and meningioma cells and reverses the Schwann cell phenotype. In addition, VT3989 exerts a synergistic effect when combined with Osimtinib (HY-15772) in EGFR-mutant non-small cell lung cancer models, significantly delaying tumor recurrence and prolonging survival. VT3989 can be used for the research of epithelioid hemangioendothelioma, malignant pleural mesothelioma, type 2 neurofibromatosis and related advanced solid tumors .
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Cardiomyocyte proliferation promoting agent-1
Cardiomyocyte proliferation promoting agent-1
0 Images
Cat. No.: HY-164254
CAS No.: 2351906-71-1
Synonyms: (E/Z)-GA-002
Target:  

Large Tumor Suppressor (LATS) YAP

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

Cardiomyocyte proliferation promoting agent-1 ((E/Z)-GA-002), which is an E/Z mixture, is a cardiomyocyte proliferation promoter. GA-002 (single E configuration) is a kinase inhibitor for LATS1 and LATS2, with its IC50 values being 3.93 nM and 3.87 nM respectively. GA-002 can induce the expression of genes regulated by the Hippo pathway, inhibit the phosphorylation of YAP/TAZ, and induce the nuclear translocation of YAP .
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α-Ionone
α-Ionone
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Cat. No.: HY-N8847
CAS No.: 127-41-3
Synonyms: alpha-Ionone
Category:  

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