94

Methotrexate

94 Publications Verification

Cat. No.: HY-14519

CAS No.: 59-05-2

Purity: 99.87%

Synonyms: Amethopterin; CL14377; WR19039

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Research Areas:

Inflammation/Immunology Cancer

Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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94

Methotrexate hydrate

94 Publications Verification

Cat. No.: HY-14519B

CAS No.: 133073-73-1

Purity: 98.41%

Synonyms: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Methotrexate hydrate (Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate) is an orally active antifolate (Antifolate). Methotrexate hydrate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate hydrate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate hydrate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate hydrate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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94

Methotrexate disodium

94 Publications Verification

Cat. No.: HY-14519A

CAS No.: 7413-34-5

Purity: 99.71%

Synonyms: Amethopterin disodium; CL14377 disodium; WR19039 disodium

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Methotrexate disodium (Amethopterin disodium; CL14377 disodium; WR19039 disodium) is an orally active antifolate (Antifolate). Methotrexate disodium inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate disodium promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate disodium induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate disodium is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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55

Bucladesine sodium

55 Cited Publications

Cat. No.: HY-B0764

CAS No.: 16980-89-5

Synonyms: Dibutyryl cAMP sodium; DBcAMP sodium

Target:

PKA Reactive Oxygen Species (ROS) Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Bucladesine (Dibutyryl cAMP; DBcAMP) sodium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

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55

Bucladesine hemicalcium

55 Cited Publications

Cat. No.: HY-B0764A

CAS No.: 938448-87-4

Synonyms: Dibutyryl cAMP hemicalcium; DBcAMP hemicalcium

Target:

PKA Apoptosis Reactive Oxygen Species (ROS)

Research Areas:

Neurological Disease Cancer

Bucladesine (Dibutyryl cAMP; DBcAMP) hemicalcium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

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54

Methyllycaconitine citrate

54 Cited Publications

Cat. No.: HY-N2332A

CAS No.: 351344-10-0

Synonyms: MLA citrate

Target:

nAChR Autophagy Reactive Oxygen Species (ROS) mTOR

Research Areas:

Neurological Disease

Methyllycaconitine (MLA) citrate is a blood-brain barrier-permeable antagonist of α7 nicotinic acetylcholine receptor (α7nAChR) with an IC₅₀ of 2 nM. Methyllycaconitine citrate inhibits Aβ_25-35-induced autophagy by restoring the mTOR pathway, and prevents reactive oxygen species (ROS) production, microglial activation, reduced dopamine uptake, loss of dopaminergic terminals and catecholamine secretion. Methyllycaconitine citrate induces hippocampal glutamate efflux, enhances long-term potentiation, and improves memory acquisition. Methyllycaconitine citrate can be used in research related to Alzheimer's disease, cerebral palsy, Parkinson's disease and schizophrenia .

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