109 Results for "

Hippocampus

" in MedChemExpress (MCE) Product Catalog:

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Corticosterone

72 Publications Verification

Cat. No.: HY-B1618

CAS No.: 50-22-6

Synonyms: 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B

Category:

Neurological Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:

Glucocorticoid Receptor Endogenous Metabolite iGluR

Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

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Lonafarnib

15 Cited Publications

Cat. No.: HY-15136

CAS No.: 193275-84-2

Purity: 99.60%

Synonyms: Sch66336

Target:

Farnesyl Transferase Tau Protein RSV Akt Ras Bcl-2 Family STAT nAChR Apoptosis Autophagy

Lonafarnib (Sch66336) is an orally active, blood-brain barrier penetrant farnesyltransferase (FPTase) inhibitor. Lonafarnib increases the phosphorylation levels of Akt, CaMKII and CREB, upregulates BDNF expression in the hippocampus, elevates the content of α7nAChR on cell membranes, and blocks the isoprenylation of H-Ras. Lonafarnib repairs synapses and reverses spatial memory deficits in Aβ1-42 model mice. Lonafarnib inhibits RSV fusion and replication, and alleviates virus-induced lung injury. Lonafarnib activates the lysosomal and autophagic pathways, and reduces the phosphorylation and aggregation of tau. Lonafarnib acts synergistically with Sorafenib (HY-10201) to promote apoptosis, and inhibits the proliferation and invasion of melanoma cells. Lonafarnib inhibits the farnesylation of progerin, repairs nuclear membrane defects, and activates the cGAS-STING-STAT1 signaling pathway. Lonafarnib can be used in research related to diseases including Alzheimer's disease, viral infections, melanoma, and progeria .

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LDN-212320

9 Cited Publications

Cat. No.: HY-12741

CAS No.: 894002-50-7

Purity: 98.92%

Synonyms: LDN-0212320; OSU-0212320

Target:

EAAT

Research Areas:

Neurological Disease

LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC ^[1]

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DO34

5 Cited Publications

Cat. No.: HY-117771

CAS No.: 1848233-58-8

Purity: 99.30%

Target:

DAGL

Research Areas:

Neurological Disease Metabolic Disease

DO34 is a selective DAGL inhibitor, with an IC₅₀ of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 blocks de novo 2-AG synthesis, and suppresses tonic CB₁ receptor activation. DO34 blocks depolarization-induced suppression of excitation and inhibition in the cerebellum and hippocampus. DO34 regulates feeding behavior and locomotor activity in mice. DO34 abolishes AM251-mediated enhancement of parallel fiber-evoked excitatory postsynaptic currents in cerebellar slices from MAGL global knockout mice. DO34 can be used for the research of energy balance disorder and neuroinflammation .

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Coluracetam

3 Cited Publications

Cat. No.: HY-17553

CAS No.: 135463-81-9

Synonyms: MKC-231

Target:

iGluR

Research Areas:

Neurological Disease

Coluracetam (MKC-231) is an orally taken choline uptake enhancer. Coluracetam can improve the reduced acetylcholine levels in the hippocampus of rats and mice, enhancing learning difficulties, memory deficits, and cognitive impairments. Coluracetam induces a lower degree of hepatic venous hyperglycemia .

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UF010

2 Cited Publications

Cat. No.: HY-18976

CAS No.: 537672-41-6

Target:

JAK HDAC NF-κB Toll-like Receptor (TLR) MyD88 Interleukin Related

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

UF010 is a selective inhibitor of class I HDAC. UF010 has cytotoxicity to cancer cells and reduces neuroinflammation in the hippocampus. UF010 can be used for the research of neurological diseases .

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YF-2

2 Cited Publications

Cat. No.: HY-16531

CAS No.: 1311423-89-8

Target:

Histone Acetyltransferase

Research Areas:

Neurological Disease Cancer

YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC₅₀s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease .

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YF-2 hydrochloride

2 Cited Publications

Cat. No.: HY-16531A

CAS No.: 1312005-62-1

Target:

Histone Acetyltransferase

Research Areas:

Neurological Disease Cancer

YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC₅₀s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease .

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L-733060 hydrochloride

2 Cited Publications

Cat. No.: HY-14406A

CAS No.: 148687-76-7

Purity: 99.30%

Target:

Neurokinin Receptor

Research Areas:

Neurological Disease Cancer

L-733060 hydrochloride is a selective neurokinin-1 (NK-1) receptor antagonist. L-733060 hydrochloride mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 hydrochloride blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 hydrochloride reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 hydrochloride hydrochloride inhibits neurogenic plasma extravasation at a dose that does not cause adverse cardiovascular effects in rodents, and also acts as an anti-tumor agent. L-733060 hydrochloride can be used for the study of chronic orofacial pain .

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Enoxaparin

1 Cited Publications

Cat. No.: HY-109509

CAS No.: 679809-58-6

Synonyms: PK 10169; Enoxaparin sodium

Target:

Factor Xa Thrombin SARS-CoV

Research Areas:

Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer

Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19 .

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Oxiracetam

1 Cited Publications

Cat. No.: HY-B1715

CAS No.: 62613-82-5

Synonyms: ISF2522

Target:

GABA Receptor NO Synthase

Research Areas:

Infection Neurological Disease

Oxiracetam (ISF2522) is an orally active and a BBB-penetrable cyclic derivative of γ-aminobutyric acid (GABA). Oxiracetam reaches the hippocampus and cerebral cortex in high concentrations. Oxiracetam can promote cognitive function and regulate inflammatory response, with powerful neuroprotective effects. Oxiracetam can be used in the study of central nervous system diseases .

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Rapastinel

1 Cited Publications

Cat. No.: HY-16728

CAS No.: 117928-94-6

Synonyms: GLYX-13

Target:

iGluR ERK mTOR

Research Areas:

Neurological Disease Cancer

Rapastinel (GLYX-13) is a potent NMDAR modulator capable of crossing the blood-brain barrier, and it exhibits extremely high affinity for human NMDAR (EC₅₀=0.0017-9.9 nM). Rapastinel enhances ERK signaling and activates the mTOR pathway, thereby upregulating the expression of BDNF and VGF, and inducing significant neuroplastic changes such as enhanced LTP and increased mature dendritic spine density in the hippocampus. Rapastinel moderately elevates the efflux of dopamine, norepinephrine and 5-HT in the prefrontal cortex, and uniquely avoids side effects of traditional antidepressants such as dissociation, addiction or sedation. Rapastinel is applicable to the research of major depressive disorder and hepatocellular carcinoma .

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β-Spaglumic acid

1 Cited Publications

Cat. No.: HY-130553

CAS No.: 4910-46-7

Purity: 99.97%

Synonyms: β-NAAG; β-N-Acetylaspartylglutamic acid

Target:

Aminopeptidase mGluR

Research Areas:

Neurological Disease

β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (K_i=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies .

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Rapastinel Trifluoroacetate

1 Cited Publications

Cat. No.: HY-16728B

CAS No.: 1435786-04-1

Synonyms: GLYX-13 Trifluoroacetate

Target:

iGluR mTOR ERK

Research Areas:

Neurological Disease

Rapastinel (GLYX-13) Trifluoroacetate is a potent NMDAR modulator capable of crossing the blood-brain barrier, and it exhibits extremely high affinity for human NMDAR (EC₅₀=0.0017-9.9 nM). Rapastinel Trifluoroacetate enhances ERK signaling and activates the mTOR pathway, thereby upregulating the expression of BDNF and VGF, and inducing significant neuroplastic changes such as enhanced LTP and increased mature dendritic spine density in the hippocampus. Rapastinel Trifluoroacetate moderately elevates the efflux of dopamine, norepinephrine and 5-HT in the prefrontal cortex, and uniquely avoids side effects of traditional antidepressants such as dissociation, addiction or sedation. Rapastinel Trifluoroacetate is applicable to the research of major depressive disorder and hepatocellular carcinoma .

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