1467 Results for "

Humanly relevant dose

" in MedChemExpress (MCE) Product Catalog:

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646

Lipopolysaccharides, from E. coli O55:B5

646 Publications Verification

Cat. No.: HY-D1056

Synonyms: LPS, from Escherichia coli (O55:B5)

Category:

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:

Toll-like Receptor (TLR)

Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 can be widely used to induce cellular inflammation and establish animal models related to inflammation .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

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104

PLX5622

104 Cited Publications

Cat. No.: HY-114153

CAS No.: 1303420-67-8

Purity: 99.79%

Target:

c-Fms

Research Areas:

Neurological Disease Inflammation/Immunology

PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC₅₀=0.016 μM; K_i=5.9 nM). PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 is an ideal choose for microglia function research in healthy or diseased states. PLX5622 has been verified by MedChemExpress, which demonstrates desirable microglia depletion efficiency in mice. PLX5622 is predominantly administered via ad libitum diets with a dose of 1200 ppm .

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Defactinib hydrochloride

67 Cited Publications

Cat. No.: HY-12289A

CAS No.: 1073160-26-5

Purity: 99.35%

Synonyms: VS-6063 hydrochloride; PF 04554878 hydrochloride

Target:

FAK

Research Areas:

Cancer

Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

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