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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
253 Results for "
Hybrid strategy
" in MedChemExpress (MCE) Product Catalog:
Products (253)
253 Results for "Hybrid strategy" in MCE Product Catalog:
34
34 Publications Verification
Synonyms: Peposertib; M3814
Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity .
13
13 Cited Publications
Synonyms: Phen-DC3 Triflate
Target:
Research Areas:
Phen-DC3 Trifluoromethanesulfonate is a bisquinolinium G-quadruplex (G4) ligand. Phen-DC3 Trifluoromethanesulfonate selectively binds to and stabilizes the hybrid quadruplex-duplex hybrid (QDH) derived from the PIM1 promoter. Phen-DC3 Trifluoromethanesulfonate also binds to the c-myc promoter Pu24T G4 via extensive π-stacking, and induces polymerase stalling at α-synuclein DNA and RNA G4 sequences. Phen-DC3 Trifluoromethanesulfonate downregulates LPS (HY-D1056)-induced TNFRSF21, RIPK3 and p-MLKL in VECs, and ameliorates CLP-induced pulmonary vascular leakage in septic rats. Phen-DC3 Trifluoromethanesulfonate can be used in studies related to neurodegenerative diseases and sepsis-associated vascular injury .
5
5 Cited Publications
Cat. No.: HY-N1476
CAS No.: 145459-19-4
Category:
Plant Caryophyllaceae Extract Cyclopeptides Pseudostellaria heterophylla (Miq.) Pax Extract Other Families Extract Disease Research Fields Cancer
Target:
1
1 Cited Publications
ERX-41 is an orally active and stereospecific small molecule targeting to lysosomal acid lipase A (LIPA). ERX-41 induces endoplasmic reticulum (ER) stress resulting in cell death, indicating a function independent of LIPA but dependent on its ER localization. ERX-41 involves in a targeted strategy for solid tumors .
1
1 Cited Publications
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Research Areas:
TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells .
1
1
1 Cited Publications
Cat. No.: HY-W010056
CAS No.: 623-91-6
Target:
1
1 Cited Publications
Cat. No.: HY-W105970
CAS No.: 7758-16-9
Synonyms: Disodium pyrophosphate; Sodium acid pyrophosphate; SAPP
1
Category:
Geraniaceae Extract Plant Neurological Disease Pelargonium hortorum Bailey Extract Liliaceae Extract Anemarrhena asphodeloides Bunge Extract Disease Research Fields Steroids
Target:
1
1 Cited Publications
Cat. No.: HY-N6841
CAS No.: 86831-53-0
Cat. No.: HY-E70135
CAS No.: 37278-88-9
Synonyms: Endo F1
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Research Areas:
Endo-β-N-acetylglucosaminidase F1 (Endo F1) cleaves Asparagine-linked high mannose and some hybrid oligosaccharides .
Synonyms: ALN-AT3SC; SAR439774
Research Areas:
Fitusiran (ALN-AT3SC) is a siRNA strategy. Fitusiran delivers siRNA targeting the SERPINC1 gene in hepatocytes to inhibit antithrombin synthesis. Fitusiran enhances thrombin activity and increases Thrombin generation, thereby restoring hemostatic function. Fitusiran can be used in hemophilia-related research .
Category:
Vitaceae Extract Plant Ketones, Aldehydes, Acids Other Diseases Other Families Extract Microorganism Disease Research Fields Vitis vinifera cv. Zalema Extract
Target:
Cat. No.: HY-D0284
CAS No.: 36888-99-0
Cat. No.: HY-P3383
CAS No.: 850761-47-6
Synonyms: PL-5
Cat. No.: HY-W011548
CAS No.: 2096-10-8
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Research Areas:
2-Aminoadenosine is a modified adenine base and adenosine analog that stabilizes RNA duplexes and enhances template-directed nucleotide condensation reactions. 2-Aminoadenosine forms three hydrogen bonds with uracil to increase the melting temperature of hybrid strands, thereby stabilizing uracil-containing RNA duplexes .
Cat. No.: HY-W089777
CAS No.: 2530-83-8
Synonyms: GPTMS
Cat. No.: HY-E70573
Target:
Research Areas:
Endo SH is a fusion protein of Endo S (from Streptococcus pyogenes) and Endo H (from Streptomyces plicatus), expressed in Escherichia coli. Endo SH can cleave the chitobiose core structure of high mannose, complex and some hybrid oligosaccharides in N-glycoproteins, remove N-linked high mannose in glycoproteins, and can completely replace Endo S and Endo H.
Cat. No.: HY-16532
CAS No.: 139570-93-7
Synonyms: AEZS-108; AN-152
Research Areas:
Synonyms: PA-5HT
Target:
Research Areas:
Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, antagonist of FAAH. Palmitoyl serotonin inhibits L-3,4-dihydroxyphenylalanine (HY-N0304) induced abnormal involuntary movements. Palmitoyl serotonin has the potential for the research of parkinson's disease (PD) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
