3192 Results for "

IDE knockout mice

" in MedChemExpress (MCE) Product Catalog:

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333

Stattic

333 Publications Verification

Cat. No.: HY-13818

CAS No.: 19983-44-9

Purity: 99.58%

Target:

STAT Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727) . Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3 . Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice .

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282

Tamoxifen

282 Cited Publications

Cat. No.: HY-13757A

CAS No.: 10540-29-1

Purity: 99.78%

Synonyms: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen

Target:

Estrogen Receptor/ERR HSP Autophagy Apoptosis

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757) .

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282

Tamoxifen Citrate

282 Cited Publications

Cat. No.: HY-13757

CAS No.: 54965-24-1

Purity: 99.93%

Synonyms: ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate

Target:

Estrogen Receptor/ERR HSP Autophagy Apoptosis

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis. Tamoxifen Citrate can also be used to induce gene knockout in CreER transgenic mice .

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243

Pevonedistat hydrochloride

243 Cited Publications

Cat. No.: HY-10484

CAS No.: 1160295-21-5

Purity: 98.58%

Synonyms: MLN4924 hydrochlorIDE

Target:

NEDD8-activating Enzyme Apoptosis

Research Areas:

Cancer

Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC₅₀ of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice .

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243

Pevonedistat

243 Cited Publications

Cat. No.: HY-70062

CAS No.: 905579-51-3

Synonyms: MLN4924

Target:

NEDD8-activating Enzyme Apoptosis

Research Areas:

Cancer

Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC₅₀ of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice .

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182

ATP

182 Cited Publications

Cat. No.: HY-B2176

CAS No.: 56-65-5

Synonyms: Adenosine 5'-triphosphate

Category:

Plants Other Families Extract Endogenous metabolite Alkaloids Human Gut Microbiota Metabolites Microorganisms Animals Other Alkaloids Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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182

ATP dimagnesium

182 Cited Publications

Cat. No.: HY-B2176B

CAS No.: 74804-12-9

Synonyms: Adenosine 5'-triphosphate dimagnesium

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation. ATP dimagnesium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP dimagnesium has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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182

ATP disodium trihydrate

182 Cited Publications

Cat. No.: HY-B2176A

CAS No.: 51963-61-2

Synonyms: Adenosine-5'-triphosphate disodium trihydrate

Category:

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial

ATP (Adenosine 5'-triphosphate) disodium trihydrate is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation. ATP disodium trihydrate can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium trihydrate has anti-bacterial infection effects and can protect mice against bacterial infection in mice .

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