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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
II399
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "II399" in MCE Product Catalog:
Cat. No.: HY-163174
CAS No.: 2928480-72-0
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II399 is a nicotinamide N-methyltransferase (NNMT) inhibitor (human NNMT IC50 = 0.049-8.800 μM; Ki = 5.9-77 nM; Kd = 336 nM). II399 competitively blocks the transfer of methyl from SAM to nicotinamide by occupying the Nicotinamide (HY-B0150) and SAM binding pockets, and inhibits NNMT-mediated shunting of nicotinamide from the NAD + salvage pathway. II399 reduces cellular MNA, inhibits renal cancer cell viability, and in combination with SHMT2/MEPCE inhibits lipotoxicity and Cholesterol (from animal) (HY-N0322)-induced hepatocyte injury. II399 can be used for research on clear cell renal cell carcinoma and cholesterol-induced hepatotoxicity .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
