337 Results for "

IL-17

" in MedChemExpress (MCE) Product Catalog:
Products (337)

337 Results for "IL-17" in MCE Product Catalog:

24
SGC-CBP30
SGC-CBP30
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24 Publications Verification
Cat. No.: HY-15826
CAS No.: 1613695-14-9
Purity:  99.60%
Target:  

Epigenetic Reader Domain Histone Acetyltransferase

Research Areas:  

Inflammation/Immunology Cancer

SGC-CBP30, a chemical probe, is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects .
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13
Secukinumab (Anti-Human IL-17A)
Secukinumab (Anti-Human IL-17A)
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13 Cited Publications
Cat. No.: HY-P9927A
CAS No.: 1229022-83-6

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Secukinumab (Anti-Human IL-17A) is a fully human anti-interleukin-17A monoclonal antibody. Anti-Human IL-17A can be used for research in psoriasis pathogenesis .
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13
Secukinumab
Secukinumab
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13 Cited Publications
Cat. No.: HY-P9927
CAS No.: 1229022-83-6
Synonyms: AIN457

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis .
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12
IL-17A Protein, Human (HEK293, His)
IL-17A Protein, Human (HEK293, His)
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12 Cited Publications
Cat. No.: HY-P70527
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17A; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-Lymphocyte-Assoc
Species:  
Human
Source:  
HEK293
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7
Y-320
Y-320
0 Images
7 Cited Publications
Cat. No.: HY-15898
CAS No.: 288250-47-5
Purity:  99.03%
Target:  

Interleukin Related Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .
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6
IL-17A Protein, Human
IL-17A Protein, Human
0 Images
6 Cited Publications
Cat. No.: HY-P7036
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17A; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-Lymphocyte-Associated Antigen 8
Species:  
Human
Source:  
E. coli
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5
IL-17A Protein, Mouse (HEK293, His)
IL-17A Protein, Mouse (HEK293, His)
0 Images
5 Cited Publications
Cat. No.: HY-P70753
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17A; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-Lymphocyte-Assoc
Species:  
Mouse
Source:  
HEK293
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5
2'-Fucosyllactose
2'-Fucosyllactose
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5 Cited Publications
Cat. No.: HY-N9965
CAS No.: 41263-94-9
Synonyms: 2'-FL
Category:  

Infection Polysaccharides Animals Disease Research Fields Inflammation/Immunology Saccharides

Target:  

TNF Receptor Interleukin Related

2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines .
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4
LY3509754
LY3509754
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4 Cited Publications
Cat. No.: HY-139206
CAS No.: 2452464-73-0
Purity:  99.65%
Synonyms: IL-17A inhibitor 1
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

LY3509754 (IL-17A inhibitor 1) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells .
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4
GSK2981278
GSK2981278
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4 Cited Publications
Cat. No.: HY-19770
CAS No.: 1474110-21-8
Target:  

ROR

Research Areas:  

Inflammation/Immunology

GSK2981278 is a potent and selective RORγ inverse agonist. GSK2981278 inhibits activation of the il17 promoter and interferes RORγ-DNA binding .
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3
IL-17A antagonist 1
IL-17A antagonist 1
0 Images
3 Cited Publications
Cat. No.: HY-101913
CAS No.: 2205034-18-8
Purity:  99.74%
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

IL-17A antagonist 1 is an interleukin-17A (IL-17A) antagonist with an IC50 of 1.14 μM and a Kd of 0.66 μM. IL-17A antagonist 1 binds specifically and exclusively to the IL-17A homodimer at its central dimer interface pocket, induces a large conformational change that widens the pocket, and disrupts the IL-17A/IL-17RA interaction. IL-17A antagonist 1 does not bind to IL-17F or IL-17RA .
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3
IL-17A Protein, Rat (CHO)
IL-17A Protein, Rat (CHO)
0 Images
3 Cited Publications
Cat. No.: HY-P79326
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17A; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-Lymphocyte-Assoc
Species:  
Rat
Source:  
CHO
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3
Animal-Free IL-17A Protein, Mouse (His)
Animal-Free IL-17A Protein, Mouse (His)
0 Images
3 Cited Publications
Cat. No.: HY-P700194AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17A; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-Lymphocyte-Assoc
Species:  
Mouse
Source:  
E. coli
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3
Ixekizumab
Ixekizumab
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3 Cited Publications
Cat. No.: HY-P9924
CAS No.: 1143503-69-8
Synonyms: LY2439821

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A (KD<3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis .
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3
SR0987
SR0987
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3 Cited Publications
Cat. No.: HY-101454
CAS No.: 303126-97-8
Purity:  99.65%
Target:  

ROR

Research Areas:  

Inflammation/Immunology Cancer

SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1 .
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3
AX-024
AX-024
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3 Cited Publications
Cat. No.: HY-107390
CAS No.: 1370544-73-2
Purity:  99.29%
Target:  

TNF Receptor Interleukin Related IFNAR

Research Areas:  

Inflammation/Immunology Cancer

AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
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3
AX-024 hydrochloride
AX-024 hydrochloride
0 Images
3 Cited Publications
Cat. No.: HY-107390A
CAS No.: 1704801-24-0
Purity:  99.75%
Target:  

TNF Receptor Interleukin Related IFNAR

Research Areas:  

Inflammation/Immunology Cancer

AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
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3
Hyperforin dicyclohexylammonium salt
Hyperforin dicyclohexylammonium salt
0 Images
3 Cited Publications
Cat. No.: HY-116330A
CAS No.: 238074-03-8
Purity:  99.52%
Synonyms: Hyperforin DCHA
Category:  

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