144 Results for "

IL-17a

" in MedChemExpress (MCE) Product Catalog:
Products (144)

144 Results for "IL-17a" in MCE Product Catalog:

24
SGC-CBP30
SGC-CBP30
0 Images
24 Publications Verification
Cat. No.: HY-15826
CAS No.: 1613695-14-9
Purity:  99.60%
Target:  

Epigenetic Reader Domain Histone Acetyltransferase

Research Areas:  

Inflammation/Immunology Cancer

SGC-CBP30, a chemical probe, is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects .
loading...
    loading...
View All Sizes
13
Secukinumab
Secukinumab
0 Images
13 Cited Publications
Cat. No.: HY-P9927
CAS No.: 1229022-83-6
Synonyms: AIN457

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis .
loading...
    loading...
View All Sizes
13
Secukinumab (Anti-Human IL-17A)
Secukinumab (Anti-Human IL-17A)
0 Images
13 Cited Publications
Cat. No.: HY-P9927A
CAS No.: 1229022-83-6

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Secukinumab (Anti-Human IL-17A) is a fully human anti-interleukin-17A monoclonal antibody. Anti-Human IL-17A can be used for research in psoriasis pathogenesis .
loading...
    loading...
View All Sizes
12
IL-17A Protein, Human (HEK293, His)
IL-17A Protein, Human (HEK293, His)
0 Images
12 Cited Publications
Cat. No.: HY-P70527
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17a; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17a; Prev. IL17; CTLA-8; IL-17a; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17a; Cytotoxic T-Lymphocyte-Assoc
Species:  
Human
Source:  
HEK293
loading...
    loading...
View All Sizes
6
IL-17A Protein, Human
IL-17A Protein, Human
0 Images
6 Cited Publications
Cat. No.: HY-P7036
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17a; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17a; Prev. IL17; CTLA-8; IL-17a; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17a; Cytotoxic T-Lymphocyte-Associated Antigen 8
Species:  
Human
Source:  
E. coli
loading...
    loading...
View All Sizes
5
IL-17A Protein, Mouse (HEK293, His)
IL-17A Protein, Mouse (HEK293, His)
0 Images
5 Cited Publications
Cat. No.: HY-P70753
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17a; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17a; Prev. IL17; CTLA-8; IL-17a; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17a; Cytotoxic T-Lymphocyte-Assoc
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
View All Sizes
4
LY3509754
LY3509754
0 Images
4 Cited Publications
Cat. No.: HY-139206
CAS No.: 2452464-73-0
Purity:  99.65%
Synonyms: IL-17a inhibitor 1
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

LY3509754 (IL-17A inhibitor 1) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells .
loading...
    loading...
View All Sizes
3
Ixekizumab
Ixekizumab
0 Images
3 Cited Publications
Cat. No.: HY-P9924
CAS No.: 1143503-69-8
Synonyms: LY2439821

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A (KD<3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis .
loading...
    loading...
View All Sizes
3
IL-17A antagonist 1
IL-17A antagonist 1
0 Images
3 Cited Publications
Cat. No.: HY-101913
CAS No.: 2205034-18-8
Purity:  99.74%
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

IL-17A antagonist 1 is an interleukin-17A (IL-17A) antagonist with an IC50 of 1.14 μM and a Kd of 0.66 μM. IL-17A antagonist 1 binds specifically and exclusively to the IL-17A homodimer at its central dimer interface pocket, induces a large conformational change that widens the pocket, and disrupts the IL-17A/IL-17RA interaction. IL-17A antagonist 1 does not bind to IL-17F or IL-17RA .
loading...
    loading...
View All Sizes
3
IL-17A Protein, Rat (CHO)
IL-17A Protein, Rat (CHO)
0 Images
3 Cited Publications
Cat. No.: HY-P79326
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17a; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17a; Prev. IL17; CTLA-8; IL-17a; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17a; Cytotoxic T-Lymphocyte-Assoc
Species:  
Rat
Source:  
CHO
loading...
    loading...
View All Sizes
3
Animal-Free IL-17A Protein, Mouse (His)
Animal-Free IL-17A Protein, Mouse (His)
0 Images
3 Cited Publications
Cat. No.: HY-P700194AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17a; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17a; Prev. IL17; CTLA-8; IL-17a; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17a; Cytotoxic T-Lymphocyte-Assoc
Species:  
Mouse
Source:  
E. coli
loading...
    loading...
View All Sizes
3
AX-024
AX-024
0 Images
3 Cited Publications
Cat. No.: HY-107390
CAS No.: 1370544-73-2
Purity:  99.29%
Target:  

TNF Receptor Interleukin Related IFNAR

Research Areas:  

Inflammation/Immunology Cancer

AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
loading...
    loading...
View All Sizes
3
AX-024 hydrochloride
AX-024 hydrochloride
0 Images
3 Cited Publications
Cat. No.: HY-107390A
CAS No.: 1704801-24-0
Purity:  99.75%
Target:  

TNF Receptor Interleukin Related IFNAR

Research Areas:  

Inflammation/Immunology Cancer

AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
loading...
    loading...
View All Sizes
2
Anti-Mouse/Rat IL-17A Antibody (17F3)
Anti-Mouse/Rat IL-17A Antibody (17F3)
0 Images
2 Cited Publications
Cat. No.: HY-P990222

Target:  

Interleukin Related

Research Areas:  

Metabolic Disease Inflammation/Immunology

Anti-Mouse/Rat IL-17A Antibody (17F3) is a mouse-derived IgG1κ type antibody inhibitor, targeting to mouse and rat IL-17A. Anti-Mouse IL-17A Antibody (17F3) can neutralize IL-17. Anti-Mouse/Rat IL-17A Antibody (17F3) can be used for the researches of infection, immunology and metabolic disease, such as M.intracellulare infection and diabetes .
loading...
    loading...
View All Sizes
2
IL-17A modulator-2
IL-17A modulator-2
0 Images
2 Cited Publications
Cat. No.: HY-145429
CAS No.: 2748749-47-3
Purity:  98.44%
Target:  

Interleukin Related

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

IL-17A modulator-2 is a IL-17A modulator, extracted from patent WO2021239743+A1, example 27. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC50 of 8.3. IL-17A modulator-2 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders .
loading...
    loading...
View All Sizes
2
IL-17A Protein, Mouse (CHO)
IL-17A Protein, Mouse (CHO)
0 Images
2 Cited Publications
Cat. No.: HY-P7372
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17a; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17a; Prev. IL17; CTLA-8; IL-17a; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17a; Cytotoxic T-Lymphocyte-Assoc
Species:  
Mouse
Source:  
CHO
loading...
    loading...
View All Sizes
2
IL-17A Protein, Human (CHO, His)
IL-17A Protein, Human (CHO, His)
0 Images
2 Cited Publications
Cat. No.: HY-P7373
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL17a; Cytotoxic T-Lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17a; Prev. IL17; CTLA-8; IL-17a; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Interleukin 17a; Cytotoxic T-Lymphocyte-Assoc
Species:  
Human
Source:  
CHO
loading...
    loading...
View All Sizes
2
IL17A Antibody
IL17A Antibody
0 Images
2 Cited Publications
Cat. No.: HY-P81114
Synonyms: Interleukin-17a; CTLA-8; CTLA 8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17a; IL-17a; IL-17; Interleukin 17; Interleukin-17; Interleukin 17a; Interleukin17; Interleukin17a; IL17_HUMAN; IL17_MOUSE.

Host:  

Rabbit

Application:  

WB, ELISA, IHC-P, IHC-F, ICC/IF

Reactivity:  

Mouse, Rat

loading...
    loading...
View All Sizes
2
Noreugenin
Noreugenin
0 Images
2 Cited Publications
Cat. No.: HY-N3029
CAS No.: 1013-69-0
Category:  

Natural Products 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.