16 Results for "

IL-8 mRNA

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "IL-8 mRNA" in MCE Product Catalog:

1
CH 275
CH 275
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1 Cited Publications
Cat. No.: HY-P1206
CAS No.: 174688-78-9
Target:  

Somatostatin Receptor

Research Areas:  

Neurological Disease

CH 275 is a peptidic somatostatin analog that acts as an agonist of SST1 (IC50 = 30.9 nM, Ki = 52 nM). The IC50 values of CH 275 for sst3, sst4, sst2, and sst5 are 345 nM, >1 μM, >10 μM, and >10 μM, respectively. CH 275 binds to SSTR1 via the IAmp9-Asp137 ion pair interaction and the hydrophobic interaction between the isopropyl group of IAmp9 and Leu107, and reduces the extracellular acidification rate. CH 275 induces weak sst1 internalization, exerts immunosuppressive effects on macrophages, and decreases macrophage viability, MCP-1 expression/secretion, and IL-8 secretion, but does not alter proMMP-9 secretion or IL-8 mRNA levels. CH 275 reduces hippocampal β-amyloid levels and alleviates plaque pathology without inducing hippocampal microglial activation. CH 275 is used in research on Alzheimer's disease, Parkinson's disease, and depression .
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Regaloside B
Regaloside B
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Cat. No.: HY-N7688
CAS No.: 114420-67-6
Category:  

Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Plants Liliaceae Extract Disease Research Fields Inflammation/Immunology 500 - Internal Server Error | MedChemExpress

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