97 Results for "

IL15

" in MedChemExpress (MCE) Product Catalog:
Products (97)

97 Results for "IL15" in MCE Product Catalog:

9
Ritlecitinib
Ritlecitinib
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9 Publications Verification
Cat. No.: HY-100754
CAS No.: 1792180-81-4
Purity:  99.43%
Synonyms: PF-06651600
Target:  

JAK Interleukin Related STAT

Research Areas:  

Inflammation/Immunology

Ritlecitinib (PF-06651600) is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .
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9
Ritlecitinib tosylate
Ritlecitinib tosylate
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9 Publications Verification
Cat. No.: HY-100754C
CAS No.: 2192215-81-7
Purity:  99.77%
Synonyms: PF-06651600 tosylate
Target:  

JAK Interleukin Related STAT

Research Areas:  

Inflammation/Immunology

Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .
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7
Y-320
Y-320
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7 Cited Publications
Cat. No.: HY-15898
CAS No.: 288250-47-5
Purity:  99.03%
Target:  

Interleukin Related Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .
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4
IL-15R alpha & IL-15 Protein, Human (HEK293, His)
IL-15R alpha & IL-15 Protein, Human (HEK293, His)
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4 Cited Publications
Cat. No.: HY-P77699
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15RA; IL-15 Receptor Subunit Alpha; Interleukin 15 Receptor Subunit Alpha; IL15RA Protein; Interleukin-15 Receptor Subunit Alpha; CD215 Antigen; IL-15RA; IL-15R-Alpha; CD215; IL15ra; Interleukin 15 Receptor, Alpha; IL15; Interleukin-15; Interleukin 15;
Species:  
Human
Source:  
HEK293
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4
IL-15 Protein, Human
IL-15 Protein, Human
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4 Cited Publications
Cat. No.: HY-P7034
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15; Interleukin-15; Interleukin 15; MGC9721; IL-15
Species:  
Human
Source:  
E. coli
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3
Animal-Free IL-15 Protein, Mouse (His)
Animal-Free IL-15 Protein, Mouse (His)
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3 Cited Publications
Cat. No.: HY-P700193AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15; Interleukin-15; Interleukin 15; MGC9721; IL-15
Species:  
Mouse
Source:  
E. coli
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3
IL-15R alpha & IL-15 Protein, Mouse (HEK293, His)
IL-15R alpha & IL-15 Protein, Mouse (HEK293, His)
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3 Cited Publications
Cat. No.: HY-P78558
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15RA; IL-15 Receptor Subunit Alpha; Interleukin 15 Receptor Subunit Alpha; IL15RA Protein; Interleukin-15 Receptor Subunit Alpha; CD215 Antigen; IL-15RA; IL-15R-Alpha; CD215; IL15ra; Interleukin 15 Receptor, Alpha; IL15; Interleukin-15; Interleukin 15;
Species:  
Mouse
Source:  
HEK293
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2
Tofersen
Tofersen
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2 Cited Publications
Cat. No.: HY-132580
CAS No.: 2088232-70-4
Purity:  96.53%
Synonyms: BIIB067; ISIS-SOD1Rx; ISIS 333611
Target:  

SOD

Research Areas:  

Neurological Disease

Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
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2
Tofersen sodium
Tofersen sodium
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2 Cited Publications
Cat. No.: HY-132580A
CAS No.: 1898254-60-8
Purity:  97.19%
Synonyms: BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium
Target:  

SOD

Research Areas:  

Neurological Disease

Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
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1
GMP IL-15 Protein, Human
GMP IL-15 Protein, Human
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1 Cited Publications
Cat. No.: HY-P70776G
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15; Interleukin-15; Interleukin 15; MGC9721; IL-15
Species:  
Human
Source:  
E. coli
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1
IL-15 Protein, Mouse (HEK293, Fc)
IL-15 Protein, Mouse (HEK293, Fc)
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1 Cited Publications
Cat. No.: HY-P78719
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15; Interleukin-15; Interleukin 15; MGC9721; IL-15
Species:  
Mouse
Source:  
HEK293
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1
IL-15R alpha & IL-15 Protein, Human (HEK293, Fc)
IL-15R alpha & IL-15 Protein, Human (HEK293, Fc)
0 Images
1 Cited Publications
Cat. No.: HY-P70655
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15RA; IL-15 Receptor Subunit Alpha; Interleukin 15 Receptor Subunit Alpha; IL15RA Protein; Interleukin-15 Receptor Subunit Alpha; CD215 Antigen; IL-15RA; IL-15R-Alpha; CD215; IL15ra; Interleukin 15 Receptor, Alpha; IL15; Interleukin-15; Interleukin 15;
Species:  
Human
Source:  
HEK293
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1
IL-15 Protein, Human (His)
IL-15 Protein, Human (His)
0 Images
1 Cited Publications
Cat. No.: HY-P7371
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15; Interleukin-15; Interleukin 15; MGC9721; IL-15
Species:  
Human
Source:  
E. coli
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Ordesekimab
Ordesekimab
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Cat. No.: HY-P99410
CAS No.: 879293-15-9
Synonyms: AMG 714; PRV-015

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD) .
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Anti-Mouse IL-15 Antibody (AIO.3)
Anti-Mouse IL-15 Antibody (AIO.3)
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Cat. No.: HY-P990223

Target:  

Interleukin Related

Research Areas:  

Infection Inflammation/Immunology Cancer

Anti-Mouse IL-15 Antibody (AIO.3) is a rat-derived IgG2a λ type antibody inhibitor, targeting to mouse IL-15. Anti-Mouse IL-15 Antibody (AIO.3) can neutralize IL-15. Anti-Mouse IL-15 Antibody (AIO.3) can be used for the researches of cancer, infection and inflammation, such as hepatitis virus infection and esophagitis .
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HODHBt
HODHBt
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Cat. No.: HY-Y0493
CAS No.: 28230-32-2
Synonyms: HOOBt
Target:  

STAT HIV

Research Areas:  

Infection Cancer

HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer .
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IL-15-IN-1
IL-15-IN-1
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Cat. No.: HY-102049
CAS No.: 1831830-20-6
Purity:  99.79%
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

IL-15-IN-1 (compound 76) is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM .
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Neoprzewaquinone A
Neoprzewaquinone A
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Cat. No.: HY-N3201
CAS No.: 630057-39-5
Category:  

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