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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
INK4C
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "INK4C" in MCE Product Catalog:
2
INK4C-IN-2 is a p18 INK4C inhibitor. NK4C-IN-2 promotes hematopoietic stem cells (HSCs) division by inhibiting INK4C and activating CDK4/6, with an ED50 of 5.21 nM. INK4C-IN-2 shows no cytotoxic to normal 32D cells, HSCs, leukemia cell lines and myeloma cell lines .
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P18IN003 is a potent p18(INK4C) inhibitor andspecifically block the activity of p18 protein. P18IN003 has the potential to be aneffective chemical agent for therapeutic expansion of HSC .
Cat. No.: HY-123592
CAS No.: 1111287-26-3
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INK4C-IN-3 is a synthetic coumarin amide compound and a small-molecule inhibitor of INK4C (p18INK4C). INK4C-IN-3 promotes the ex vivo expansion of human and mouse hematopoietic stem cells. INK4C-IN-3 can be used in research related to hematopoietic stem cell expansion .
Cat. No.: HY-RS02417
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CDKN2C Human Pre-designed siRNA Set A contains three designed siRNAs for CDKN2C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P70034
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CDKN2C; P18-INK4C; Cyclin Dependent Kinase Inhibitor 2C; Cyclin-Dependent Kinase 6 Inhibitor P18; Cyclin-Dependent Kinase 4 Inhibitor C; Cyclin-Dependent Kinase Inhibitor 2C; P18-INK6; Cyclin-Dependent Inhibitor; INK4C; CDK6 Inhibitor P18; P18; P18-INK4C
Species:
Human
Source:
E. coli
Cat. No.: HY-116923
CAS No.: 20535-76-6
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p18SMI-21 is a novel INK4C inhibitor that specifically blocks the biological activity of p18 protein. p18SMI-21 exerts its anti-gastric acid effect through direct contact, and the intensity of this effect varies with the dose. p18SMI-21 can significantly reduce the proteolytic activity of pepsin under certain conditions. The inhibitory effect of p18SMI-21 is best achieved in direct contact with the substrate. If it contacts the substrate first, the inhibitory effect will be lost .
Cat. No.: HY-102088
CAS No.: 77408-67-4
P18IN011 is an inhibitor that specifically targets the interaction between p18(INK4C) and CDK6, with an IC50 of 3.61 μM against mouse p18INK4C. P18IN011 relieves p18-mediated CDK6 inhibition, thereby effectively regulating the G1 phase cell cycle checkpoint. P18IN011 significantly enhances the proliferation, self-renewal and bone marrow reconstitution abilities of hematopoietic stem cells, and increases the frequency of primitive hematopoietic cells to promote cobblestone area formation. Acting specifically on p18-expressing hematopoietic cells via CDK4/6, P18IN011 not only supports the ex vivo expansion of human umbilical cord blood hematopoietic stem cells, but also maintains their long-term reconstitution capacity during in vitro culture to enable multi-lineage transplantation .
Cat. No.: HY-RS18854
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Cdkn2c Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdkn2c gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
