11 Results for "

INS-1 cells

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "INS-1 cells" in MCE Product Catalog:

2
Rubusoside
Rubusoside
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2 Cited Publications
Cat. No.: HY-N0668
CAS No.: 64849-39-4
Category:  

Terpenoids Other Diseases Diterpenoids Plants Other Families Extract Disease Research Fields Sweeteners Food Research

Target:  

GLUT Amylases NF-κB

Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase) .
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2
Globalagliatin
Globalagliatin
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2 Cited Publications
Cat. No.: HY-13529
CAS No.: 1234703-40-2
Purity:  ≥98.0%
Synonyms: LY2608204; SY-004
Target:  

Glucokinase

Research Areas:  

Metabolic Disease

Globalagliatin (LY2608204) is an orally active glucokinase (GK) activator with an EC50 of 42 nM. Globalagliatin also stimulates glucose metabolism in rat insulinoma INS1-E cells with an EC50 of 579 nM. Globalagliatin targets both pancreatic β-cells and hepatocytes. Globalagliatin is promising for research of type 2 diabetes .
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2
MOTS-c (mouse)
MOTS-c (mouse)
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2 Cited Publications
Cat. No.: HY-P10769
CAS No.: 2209854-03-3
Target:  

AMPK Apoptosis

Research Areas:  

Metabolic Disease

MOTS-c (mouse) is a mitochondrial-derived polypeptide that can be used to regulates pancreatic cell function. MOTS-c (mouse) reduces insulin secretion and expression in INS-1E cells, and enhances glucagon secretion and expression in αTC-1 cells. MOTS-c (mouse) decreases the apoptosis in INS-1E and αTC-1. MOTS-c (mouse) counteracts diet-induced obesity and insulin resistance through AMPK activation .
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D-myo-Inositol-1,2,4,5-tetraphosphate tetrasodium salt
D-myo-Inositol-1,2,4,5-tetraphosphate tetrasodium salt
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Cat. No.: HY-173537
CAS No.: 154278-46-3
Synonyms: INS(1,2,4,5)P4 tetrasodium salt; 1,2,4,5-IP4 tetrasodium salt
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

D-myo-Inositol-1,2,4,5-tetraphosphate (DL-Ins-(1,2,4,5)P4) tetrasodium is raracemic regioisomer of myo-inositol tetrakisphosphates (IP4s). D-myo-Inositol-1,2,4,5-tetraphosphate tetrasodium is an Ins(1,4,5)P3 receptor agonist with a Ki of 11 nM. D-myo-Inositol-1,2,4,5-tetraphosphate tetrasodium induces Ca 2+ mobilization with an EC50 value of 0.22 μM in CHO cells .
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KIRA9
KIRA9
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Cat. No.: HY-145422
CAS No.: 2922507-65-9
Target:  

IRE1 Apoptosis

Research Areas:  

Others

KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis .
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D-myo-Inositol-1,3,4,5,6-pentaphosphate ammonium salt
D-myo-Inositol-1,3,4,5,6-pentaphosphate ammonium salt
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Cat. No.: HY-175042
Synonyms: INS(1,3,4,5,6)P5 ammonium salt; 1,3,4,5,6-IP5 ammonium salt
Target:  

Akt

Research Areas:  

Cancer

D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) (Ins(1,3,4,5,6)P5 (ammonium salt)) is an isomer of inositol phosphate that acts as a small and soluble second messenger in the transmission of cellular signals. D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) can bind to the PH domain of Grp1 with a Kd of 590 nM. D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) can inhibit the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells. D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) exhibits antiangiogenic activity in vitro and blocks capillary tube formation of HUVEC. D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) exerts antitumor effects against cancer xenografts in nude mice .
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Rubusoside (Standard)
Rubusoside (Standard)
0 Images
Cat. No.: HY-N0668R
CAS No.: 64849-39-4
Category:  

Terpenoids Diterpenoids Plants Other Families Extract

Target:  

GLUT Amylases NF-κB Reference Standards

Rubusoside (Standard) is the analytical standard of Rubusoside. This product is intended for research and analytical applications. Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase) .
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Cinnamtannin D1
Cinnamtannin D1
0 Images
Cat. No.: HY-N16465
CAS No.: 97233-06-2
Category:  

Lauraceae Extract Phenols Polyphenols Plants 500 - Internal Server Error | MedChemExpress

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