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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
IR-808
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "IR-808" in MCE Product Catalog:
Cat. No.: HY-D1711
CAS No.: 172971-76-5
Synonyms: IR-808
Cat. No.: HY-190596
Research Areas:
CyNPTi-29 is a NAMPT inhibitor, a multi-modal small molecule obtained by covalently coupling a NAMPT inhibitor with the dye IR-808. CyNPTi-29 depletes cellular NAD, downregulates HSP90 expression, impairs mitochondrial function, and induces ROS generation and apoptosis, inhibiting tumor cell migration and colony formation. CyNPTi-29 achieves tumor cell-specific uptake and mitochondrial localization via OATP transporter mediation, and enables near-infrared fluorescence imaging and photothermal conversion for mild photothermal intervention. CyNPTi-29 inhibits tumor proliferation and lung metastasis in 4T1 breast cancer xenograft and lung metastasis mouse models. CyNPTi-29 can be used for research on breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
