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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
ISM-PR44
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "ISM-PR44" in MCE Product Catalog:
Cat. No.: HY-189442
ISM-PR44 is an orally active PROTAC degrader targeting BTK, with a DC50 of 0.05 nM in BTK-HiBiT Ramos cells. ISM-PR44 recruits CRBN E3 ligase to induce ubiquitination and proteasomal degradation of BTK. ISM-PR44 exhibits antiproliferative and cytotoxic activities in B-cell lymphoma cells. ISM-PR44 can be used for research on B-cell lymphoma .
Cat. No.: HY-189443
Research Areas:
BTK Ligand-Linker Conjugates 1 is a BTK ligand-linker conjugate. BTK Ligand-Linker Conjugates 1 can be used to synthesize PROTAC degraders such as ISM-PR44 (HY-189442). BTK Ligand-Linker Conjugates 1 can be used for research on B-cell lymphoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
