74 Results for "

Immune checkpoints

" in MedChemExpress (MCE) Product Catalog:
Products (74)

74 Results for "Immune checkpoints" in MCE Product Catalog:

8
Monalizumab
Monalizumab
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8 Publications Verification
Cat. No.: HY-P99032
CAS No.: 1228763-95-8
Synonyms: IPH2201

Target:  

Checkpoint Kinase (Chk) IFNAR

Research Areas:  

Inflammation/Immunology Cancer

Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC) .
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6
STC-15
STC-15
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6 Cited Publications
Cat. No.: HY-156677
CAS No.: 2648257-56-9
Purity:  99.90%
Target:  

METTL3

Research Areas:  

Cancer

STC-15 is an orally active RNA methyltransferase METTL3 inhibitor with the activity of activating anti-tumor immunity and reshaping the tumor microenvironment. STC-15 inhibits tumor growth by activating anti-cancer immune responses associated with increased interferon signaling and synergizes with T-cell checkpoint blockade. STC-15 can be used in the study of proliferative diseases such as cancer and autoimmune diseases .
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6
BMS-1166
BMS-1166
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6 Cited Publications
Cat. No.: HY-102011
CAS No.: 1818314-88-3
Purity:  99.49%
Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation .
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6
BMS-1166 hydrochloride
BMS-1166 hydrochloride
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6 Cited Publications
Cat. No.: HY-102011A
CAS No.: 2113650-05-6
Purity:  99.31%
Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

BMS-1166 hydrochloride is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 hydrochloride induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 hydrochloride antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation .
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2
Tinurilimab
Tinurilimab
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2 Cited Publications
Cat. No.: HY-P99051
CAS No.: 2226224-30-0
Synonyms: BAY 1834942

Target:  

Transmembrane Glycoprotein

Research Areas:  

Inflammation/Immunology Cancer

Tinurilimab (Bay 1834942) is an anti-CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6) humanized IgG2 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors. Tinurilimab shows an increased tumor cell killing effect in the tumor-cell/T-cell co-culture system .
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2
CA-170
CA-170
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2 Cited Publications
Cat. No.: HY-101093
CAS No.: 1673534-76-3
Purity:  99.39%
Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes .
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Anti-Mouse PD-1 Antibody (S-5001)
Anti-Mouse PD-1 Antibody (S-5001)
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1 Cited Publications
Cat. No.: HY-P99144A

Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse PD-1 Antibody (S-5001) is a selective inhibitor targeting PD-1, blocking the PD-1/PD-L1 immune checkpoint axis through competitive binding to PD-1. Anti-Mouse PD-1 Antibody (S-5001) works by reversing the tumor immunosuppressive microenvironment and reactivating the anti-tumor activity of cytotoxic T lymphocytes. It can be used in research on tumors such as melanoma and HPV-positive oropharyngeal squamous cell carcinoma. Anti-Mouse PD-1 Antibody (S-5001) is often combined with photothermal therapy, chemotherapy, etc., to enhance efficacy .
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Tiragolumab
Tiragolumab
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Cat. No.: HY-P9986
CAS No.: 1918185-84-8
Synonyms: MTIG-7192A; RG-6058

Target:  

CD28

Research Areas:  

Cancer

Tiragolumab is an immune checkpoint inhibitor binding to the T-cell immunoglobulin and ITIM domain (TIGIT). Tiragolumab in combination with Atezolizumab (HY-P9904) and Bevacizumab (HY-P9906) has benefit in unresectable hepatocellular carcinoma. Tiragolumab can be used to study non-small cell lung cancer (NSCLC) and melanoma .
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EVT801
EVT801
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Cat. No.: HY-152293
CAS No.: 1412453-70-3
Target:  

VEGFR ERK

Research Areas:  

Cancer

EVT801 is an orally active and selective inhibitor of VEGFR-3 (IC50=11 nM), which has antitumor effects. EVT801 inhibits not only VEGF-C-induced human endothelial cell proliferation, but also tumor (lymphatic) angiogenesis in tumor mouse models. EVT801 can reduce tumor hypoxia, immunosuppressive cytokines (CCL4, CCL5) and myeloid derived suppressor cells (MDSC) production. EVT801 has synergistic effect with immune checkpoint therapy (ICT), which improves ICT response rate and has better inhibitory effect on cancer mouse models . EVT801 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Fianlimab
Fianlimab
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Cat. No.: HY-P99617
CAS No.: 2126132-98-5
Synonyms: REGN3767

Target:  

LAG-3

Research Areas:  

Inflammation/Immunology Cancer

Fianlimab (REGN3767) is a human monoclonal antibody that targets the immune checkpoint receptor LAG-3 on T cells and has anti-tumour activity .
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Vudalimab
Vudalimab
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Cat. No.: HY-P99166
CAS No.: 2329669-72-7
Synonyms: XmAb20717
Target:  

PD-1/PD-L1 CTLA-4

Research Areas:  

Inflammation/Immunology Cancer

Vudalimab is a potent dual PD-1 and CTLA-4 inhibitor as a fully humanized bispecific monoclonal antibody. Vudalimab targets immune checkpoint receptors PD-1 and CTLA-4 and promotes tumor-selective T-cell activation .
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Evorpacept
Evorpacept
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Cat. No.: HY-P99950
CAS No.: 2484949-51-9
Synonyms: ALX148

Target:  

CD47

Research Areas:  

Cancer

Evorpacept (ALX148) is a high-affinity CD47-blocking fusion protein with an inactive human immunoglobulin Fc region. Evorpacept binds to CD47, blocks the interaction of the CD47-SIRPα immune checkpoint, and inhibits the binding of wild-type SIRPα to CD47. Evorpacept is applicable to research related to acute myeloid leukemia .
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Arvenin I
Arvenin I
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Cat. No.: HY-N6579
CAS No.: 65247-27-0
Category:  

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