29

SKF-96365 (hydrochloride)

29 Publications Verification

Cat. No.: HY-100001

CAS No.: 130495-35-1

Purity: ≥99.01%

Target:

TRP Channel CRAC Channel Autophagy CaMK Akt Apoptosis Na+/Ca2+ Exchanger Calcium Channel

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac I_Na/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G₂/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .

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29

SKF-96365

29 Publications Verification

Cat. No.: HY-125942

CAS No.: 162849-90-3

Target:

CRAC Channel TRP Channel CaMK Akt Apoptosis Autophagy Na+/Ca2+ Exchanger Calcium Channel

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

SKF-96365 is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 inhibits voltage-gated sodium current (cardiac I_Na/NaV1.5) and slows myocardial conduction. SKF-96365 inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 induces G₂/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .

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9

GS967

9 Cited Publications

Cat. No.: HY-12593

CAS No.: 1262618-39-2

Purity: 99.55%

Target:

Sodium Channel

Research Areas:

Cardiovascular Disease

GS967 (GS-458967) is a potent, and selective inhibitor of cardiac late sodium current (late I_Na ) with IC₅₀ values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.

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6

Ranolazine

6 Cited Publications

Cat. No.: HY-B0280

CAS No.: 95635-55-5

Synonyms: CVT 303; RS 43285-003

Target:

Sodium Channel Calcium Channel

Research Areas:

Cardiovascular Disease Cancer

Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (I_Na and I_Kr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor . Antianginal agent.

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6

Ranolazine dihydrochloride

6 Cited Publications

Cat. No.: HY-17401

CAS No.: 95635-56-6

Synonyms: CVT 303 dihydrochloride; RS 43285

Target:

Calcium Channel Sodium Channel Autophagy

Research Areas:

Cardiovascular Disease Cancer

Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (I_Na and I_Kr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor .

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4

Smurf1-IN-A01

4 Cited Publications

Cat. No.: HY-110195

CAS No.: 1007647-73-5

Purity: 99.81%

Synonyms: A01

Target:

HSP Interleukin Related MyD88 NF-κB Estrogen Receptor/ERR

Research Areas:

Others Cancer

Smurf1-IN-A01 is a Smurf1 inhibitor. Smurf1-IN-A01 has anticancer activity and can be used for the research of osteoporosis and age-related macular degeneration .

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2

Mal-PEG4-NHS ester

2 Cited Publications

Cat. No.: HY-126505

CAS No.: 1325208-25-0

Purity: 99.39%

Target:

ADC Linkers

Research Areas:

Cancer

Mal-PEG4-NHS ester is a non-cleavable ADC linker which links Quantum dots (QDs) with PEGylated liposomes .

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2

Azimilide dihydrochloride

2 Cited Publications

Cat. No.: HY-18600A

CAS No.: 149888-94-8

Synonyms: NE-10064 dihydrochloride

Target:

Potassium Channel Calcium Channel Sodium Channel

Research Areas:

Cardiovascular Disease

Azimilide (NE-10064) dihydrochloride is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide dihydrochloride is a dual blocker of I_Ks (IC₅₀ = 2.6 μM (2mM [K⁺]ₑ)) and I_Kr (IC₅₀ = 1 μM (4 mM [K⁺])). Azimilide dihydrochloride blocked HERG channel at 0.1 and 1 Hz with IC₅₀s of 1.4 μM and 5.2 μM respectively. Azimilide dihydrochloride also inhibits L-type calcium current (I_Ca) (IC₅₀ = 17.8 μM) and sodium current (I_Na) (IC₅₀ = 19 μM). Azimilide dihydrochloride can be used for the study of atrial fibrillation and ventricular fibrillation .

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2

Azimilide

2 Cited Publications

Cat. No.: HY-18600

CAS No.: 149908-53-2

Synonyms: NE-10064

Target:

Potassium Channel Calcium Channel Sodium Channel

Research Areas:

Cardiovascular Disease

Azimilide (NE-10064) is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide is a dual blocker of I_Ks (IC₅₀ = 2.6 μM (2mM [K⁺]ₑ)) and I_Kr (IC₅₀ = 1 μM (4 mM [K⁺])). Azimilide blocked HERG channel at 0.1 and 1 Hz with IC₅₀s of 1.4 μM and 5.2 μM respectively. Azimilide also inhibits L-type calcium current (I_Ca) (IC₅₀ = 17.8 μM) and sodium current (I_Na) (IC₅₀ = 19 μM). Azimilide can be used for the study of atrial fibrillation and ventricular fibrillation .

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1

Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2

1 Cited Publications

Cat. No.: HY-W127716

CAS No.: 136724-73-7

Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can bu used as an effective quencher of quantum dots (QDs) fluorescence and the capture probe of virus antigen EV71. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can be used sensitive electrogenerated chemiluminescence (ECL) labels for detection of matrix metalloproteinases (MMPs) .

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Relutrigine

Cat. No.: HY-148792

CAS No.: 2392951-29-8

Purity: 99.13%

Synonyms: PRAX-562

Target:

Sodium Channel

Research Areas:

Neurological Disease

Relutrigine (PRAX-562) is an orally active inhibitor of persistent sodium channel. Relutrigine potently and preferentially inhibits persistent I_Na induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC₅₀ values of 141 nM and 75 nM, respectively. Relutrigine exhibits potent use-dependent block and reduces neuronal intrinsic excitability. Relutrigine has effective anticonvulsant activity .

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