2

Enzalutamide carboxylic acid

2 Cited Publications

Cat. No.: HY-70002B

CAS No.: 1242137-15-0

Synonyms: MDV3100 carboxylic acid

Target:

Drug Metabolite

Research Areas:

Cancer

Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist .

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2

Exisulind

2 Cited Publications

Cat. No.: HY-13633

CAS No.: 59864-04-9

Purity: 98.03%

Target:

Aldose Reductase

Research Areas:

Metabolic Disease Cancer

Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac . Exisulind inhibits aldose reductase with an IC₅₀ of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications .

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1

Acetaminophen glucuronide

1 Cited Publications

Cat. No.: HY-113083

CAS No.: 16110-10-4

Purity: ≥99.0%

Synonyms: APAP-glu

Category:

Alkaloids Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields

Target:

Drug Metabolite Endogenous Metabolite

Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

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1

Veratryl alcohol

1 Cited Publications

Cat. No.: HY-107858

CAS No.: 93-03-8

Purity: 99.98%

Synonyms: 3,4-Dimethoxybenzyl alcohol

Category:

Natural Products Microorganisms Other Diseases Disease Research Fields

Target:

Endogenous Metabolite Bacterial

Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H₂O₂ and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy .

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1

Thromboxane B2

1 Cited Publications

Cat. No.: HY-113331

CAS No.: 54397-85-2

Purity: ≥99.0%

Target:

Prostaglandin Receptor

Research Areas:

Cardiovascular Disease Inflammation/Immunology

Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation. Thromboxane B2 is a biological inactive product and circulating catabolite of thromboxane A2. Thromboxane B2 levels in peripheral venous blood and coronary sinus blood can be used as a diagnostic marker for angina. Thromboxane B2 level in serum is also associated with inhibition of COX-1 activity inhibition in platelets. Thromboxane B2 is a major product of prostaglandin endoperoxide metabolism. Thromboxane B2 produces dose-related decreases in airflow rate, tidal volume and dynamic lung compliance, whilst simultaneously increasing pulmonary airway resistance in dog model. Thromboxane B2 appears to be a naturally occurring bronchoactive metabolite in the bioconversion of arachidonic acid .

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1

3-Methoxytyramine-d4 hydrochloride

1 Cited Publications

Cat. No.: HY-103638S

CAS No.: 1216788-76-9

Purity: ≥99.0%

Synonyms: 3-O-methyl Dopamine-d4 hydrochloride

3-Methoxytyramine-d₄ (hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride. 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1) .

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1

Clopidogrel carboxylic acid hydrochloride

1 Cited Publications

Cat. No.: HY-141749B

CAS No.: 144750-42-5

Purity: 99.50%

Synonyms: CLPM hydrochloride; SR 26334 hydrochloride

Target:

Drug Metabolite

Research Areas:

Cardiovascular Disease

Clopidogrel carboxylic acid (CLPM) hydrochloride is an inactive metabolite of the widely used antiplatelet medication clopidogrel, which serves as a reference standard for quantitative analysis of clopidogrel metabolism. Clopidogrel carboxylic acid hydrochloride has been shown to represent approximately 85% of circulating clopidogrel, hydrolyzed from the active form by esterases. Clopidogrel carboxylic acid hydrochloride plays a crucial role in assessing the pharmacokinetics and bioavailability of clopidogrel in various clinical and research settings.

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1

EDI048

1 Cited Publications

Cat. No.: HY-156685

CAS No.: 2767264-57-1

Purity: 99.86%

Target:

PI4K Parasite

Research Areas:

Infection Metabolic Disease Cancer

EDI048 is an orally active, gut-restricted parasiticidal agent. EDI048 specifically binds to the ATP-binding site of Cryptosporidium phosphatidylinositol 4-kinase (CpPI (4) K), blocks parasite membrane biogenesis, arrests the pathogen at the schizont stage, and thus irreversibly clears the infection. EDI048 is rapidly converted to an inactive carboxylic acid metabolite via hepatic first-pass metabolism, with extremely low systemic exposure, good safety profile, and no cardiotoxicity, genotoxicity or off-target effects. EDI048 is used in studies of intestinal cryptosporidiosis in children .

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SN-38 glucuronide

Cat. No.: HY-126373

CAS No.: 121080-63-5

Purity: 99.88%

Synonyms: SN-38G

Target:

Drug Metabolite

Research Areas:

Cancer

SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

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Deflazacort

Cat. No.: HY-13609

CAS No.: 14484-47-0

Purity: 98.98%

Target:

Glucocorticoid Receptor

Research Areas:

Inflammation/Immunology Endocrinology

Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

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Hexahydrocurcumin

Cat. No.: HY-N0929

CAS No.: 36062-05-2

Category:

Zingiberaceae Extract Phenols Polyphenols Plants 500 - Internal Server Error | MedChemExpress

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