19

Indole-3-carbinol

19 Publications Verification

Cat. No.: HY-N0170

CAS No.: 700-06-1

Synonyms: Indole-3-methanol

Category:

Alkaloids Plants Other Families Extract Endogenous metabolite Disease Research Fields Cancer Indole Alkaloids

Target:

NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite

Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

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17

Indolelactic acid

17 Cited Publications

Cat. No.: HY-113099

CAS No.: 1821-52-9

Purity: 99.99%

Synonyms: Indole-3-lactic acid

Category:

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity .

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14

Indirubin

14 Cited Publications

Cat. No.: HY-N0117

CAS No.: 479-41-4

Synonyms: Couroupitine B; Indigo red; Indigopurpurin

Category:

Alkaloids Plants Other Families Extract Disease Research Fields Cancer Indole Alkaloids

Target:

Apoptosis

Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

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12

Paxilline

12 Cited Publications

Cat. No.: HY-N6778

CAS No.: 57186-25-1

Category:

Alkaloids Microorganisms Neurological Disease Terpenoids Diterpenoids Plants Other Families Extract Disease Research Fields Indole Alkaloids

Target:

Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)

Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

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8

AXKO-0046 dihydrochloride

8 Cited Publications

Cat. No.: HY-147216A

Purity: 99.68%

Target:

Lactate Dehydrogenase

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

AXKO-0046 dihydrochloride, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC₅₀ value of 42 nM. AXKO-0046 dihydrochloride can be used for the research of cancer metabolism .

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8

AXKO-0046

8 Cited Publications

Cat. No.: HY-147216

CAS No.: 3103525-82-9

Purity: 99.77%

Target:

Lactate Dehydrogenase

Research Areas:

Cancer

AXKO-0046, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor.AXKO-0046 has LDHB inhibitory activity with an EC₅₀ value of 42 nM.AXKO-0046 can be used for the research of cancer metabolism .

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