61

61 Publications Verification

Target:

Research Areas:

Cardiovascular Disease Inflammation/Immunology

GSK484 is a PAD4 inhibitor that effectively inhibits protein citrullination and the formation of neutrophil extracellular traps (NETs) by blocking the catalytic activity of PAD4. GSK484 suppresses the production of histone H3, MHC-I expression, CD8 ⁺ T cell activation, proliferation and inflammatory cytokine release. GSK484 reduces inflammation and bone destruction in collagen-induced rheumatoid arthritis, alleviates pain and mast cell activation in sickle cell disease, and improves myocardial ischemia-reperfusion injury and experimental colitis. In addition, GSK484 restores intestinal microbial homeostasis by reversing ferroptosis-induced dysbiosis. GSK484 can be used to study the disease mechanisms of rheumatoid arthritis, sickle cell disease, thrombosis, myocardial injury, colitis and other conditions .

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44

Bardoxolone methyl

44 Cited Publications

Cat. No.: HY-13324

CAS No.: 218600-53-4

Purity: 98.92%

Synonyms: RTA 402; NSC 713200; CDDO Methyl ester

Target:

Keap1-Nrf2 SARS-CoV Virus Protease

Research Areas:

Infection Neurological Disease Inflammation/Immunology

Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC₅₀ value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) .

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25

Complete Freund's adjuvant (CFA)

25 Cited Publications

Cat. No.: HY-153808

CAS No.: 9007-81-2

Target:

Toll-like Receptor (TLR)

Research Areas:

Inflammation/Immunology

Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response .

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23

Ibuprofen sodium

23 Cited Publications

Cat. No.: HY-78131C

CAS No.: 31121-93-4

Synonyms: (±)-Ibuprofen sodium

Target:

COX Apoptosis Parasite

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

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23

Ibuprofen

23 Cited Publications

Cat. No.: HY-78131

CAS No.: 15687-27-1

Synonyms: (±)-Ibuprofen

Target:

COX Apoptosis Parasite

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

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23

Ibuprofen L-lysine

23 Cited Publications

Cat. No.: HY-100586

CAS No.: 57469-77-9

Purity: 99.91%

Synonyms: (±)-Ibuprofen L-lysine

Target:

COX Apoptosis Parasite

Research Areas:

Infection Inflammation/Immunology Cancer

Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen L-lysine inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen L-lysine is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen L-lysine can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

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17

Eriodictyol

17 Cited Publications

Cat. No.: HY-N0637

CAS No.: 552-58-9

Synonyms: Huazhongilexone

Category:

Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

Melanocortin Receptor TRP Channel

Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC₅₀=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-α in the retina and maintains the integrity of the blood-retinal barrier. Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases .

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