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7 Results for "

Insig1

" in MedChemExpress (MCE) Product Catalog:

Products (7)

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Elsulfavirine

2 Cited Publications

Cat. No.: HY-109056

CAS No.: 868046-19-9

Purity: 99.90%

Synonyms: R-1206

Target:

Drug Intermediate HIV Reverse Transcriptase Carbonic Anhydrase

Research Areas:

Infection Cancer

Elsulfavirine (R-1206) is an orally active human carbonic anhydrase (carbonic anhydrase, CA) inhibitor and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRT). Elsulfavirine also targets and blocks the interaction between adenylosuccinate lyase (ADSL) and insulin-induced gene proteins INSIG1/2, blocks SREBP-1-mediated de novo lipid synthesis, and inhibits the proliferation of liver cancer cells. The combination of Elsulfavirine and Lenvatinib (HY-10981) produces a synergistic anti-tumor effect. Elsulfavirine is converted into the active metabolite VM1500A in vivo, blocks the DNA polymerase activity of reverse transcriptase, and inhibits HIV-1 replication. Elsulfavirine exhibits a K_i of 1960 nM-52400 nM against human carbonic anhydrase isoforms including I, VII, VI, VA, VB, IX, XIII, XIV. Elsulfavirine is used in studies related to HIV-1 infection and liver cancer ^[1] .

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August 31

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Insig1 Mouse Pre-designed siRNA Set A

Cat. No.: HY-RS17851

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

Insig1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Insig1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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INSIG1 Human Pre-designed siRNA Set A

Cat. No.: HY-RS06837

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

INSIG1 Human Pre-designed siRNA Set A contains three designed siRNAs for INSIG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Insig1 Rat Pre-designed siRNA Set A

Cat. No.: HY-RS24319

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

Insig1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Insig1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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