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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
Insulitis
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "Insulitis" in MCE Product Catalog:
Cat. No.: HY-W142432
CAS No.: 2058-94-8
Research Areas:
Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation .
Cat. No.: HY-P992555
Target:
Research Areas:
Anti-Mouse BTLA/CD272 Antibody (6F7) is an anti-BTLA antibody that binds BTLA/CD272 and depletes BTLA + cells. Anti-Mouse BTLA/CD272 Antibody (6F7) increases IL-4, IL-10, IL-2, and IFN-γ expression, and decreases anti-PD-1-enhanced IL-12 (p40/p70). Anti-Mouse BTLA/CD272 Antibody (6F7) delays the onset of spontaneous diabetes in aged but not young female NOD mice, attenuates anti-PD-1-induced diabetes in both age groups, protects prediabetic NOD mice from anti-PD-1-induced insulitis, and reduces pancreatic islet B/helper T cell infiltration. Anti-Mouse BTLA/CD272 Antibody (6F7) can be used for research on type 1 diabetes and insulitis .
Cat. No.: HY-W142432S
Cat. No.: HY-P992159
Target:
Research Areas:
Anti-ZnT8 Antibody (mAb43) is a monoclonal antibody targeting the zinc transporter ZnT8, with islet-specific biodistribution characteristics. Anti-ZnT8 Antibody (mAb43) binds to extracellular ZnT8 on the surface of pancreatic β-cells and masks its insulin-co-localizing sites to block autoimmune recognition. Anti-ZnT8 Antibody (mAb43) also promotes an increase in the proportion of regulatory T cells and inhibits B cell antigen presentation, thereby effectively blocking the T cell-mediated cascade of β-cell destruction. Anti-ZnT8 Antibody (mAb43) eliminates insulitis, preserves β-cell mass and induces seroconversion of autoantibodies, without directly altering the insulin secretion function or content of β-cells. Anti-ZnT8 Antibody (mAb43) can be used for research related to type 1 diabetes .
Cat. No.: HY-P992574
Research Areas:
Anti-Mouse CD226/DNAM-1 Antibody (480.1) is a rat IgG2a κ isotype blocking monoclonal antibody targeting CD226. Anti-Mouse CD226/DNAM-1 Antibody (480.1) competitively blocks the interaction between CD226 and its ligand CD155, inhibiting CD226-mediated costimulatory signaling. Anti-Mouse CD226/DNAM-1 Antibody (480.1) reduces CD4 + and CD8 + effector T cell proliferation and IFN‑γ secretion, and elevates STAT5 phosphorylation levels in regulatory T cells. Anti-Mouse CD226/DNAM-1 Antibody (480.1) attenuates the severity of insulitis in NOD mice, reduces the risk of type 1 diabetes onset, and decreases infiltration of islet-specific IGRP-reactive CD8 + T cells. Anti-Mouse CD226/DNAM-1 Antibody (480.1) can be used for research on CD226-mediated diseases, such as type 1 diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
