263 Results for "

Internalization

" in MedChemExpress (MCE) Product Catalog:
Products (263)

263 Results for "Internalization" in MCE Product Catalog:

11
SEW​2871
SEW​2871
0 Images
11 Publications Verification
Cat. No.: HY-W008947
CAS No.: 256414-75-2
Target:  

LPL Receptor ERK Akt

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology

SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses .
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11
Siponimod
Siponimod
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11 Publications Verification
Cat. No.: HY-12355
CAS No.: 1230487-00-9
Purity:  99.95%
Synonyms: BAF-312
Target:  

LPL Receptor Potassium Channel

Research Areas:  

Infection Inflammation/Immunology

Siponimod (BAF-312) is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC50 values of 0.39 nM and 0.98 nM, respectively. Siponimod induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod can be used in research related to multiple sclerosis .
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11
Siponimod hemifumarate
Siponimod hemifumarate
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11 Publications Verification
Cat. No.: HY-12355A
CAS No.: 1234627-85-0
Purity:  99.64%
Synonyms: BAF-312 hemifumarate
Target:  

LPL Receptor Potassium Channel

Research Areas:  

Neurological Disease Inflammation/Immunology

Siponimod (BAF-312) hemifumarate is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC50 values of 0.39 nM and 0.98 nM, respectively. Siponimod hemifumarate induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod hemifumarate can be used in research related to multiple sclerosis .
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6
NUCC-390
NUCC-390
0 Images
6 Cited Publications
Cat. No.: HY-111793
CAS No.: 1060524-97-1
Purity:  98.40%
Target:  

CXCR

Research Areas:  

Neurological Disease

NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046) . NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo .
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6
Elabela(19-32)
Elabela(19-32)
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6 Cited Publications
Cat. No.: HY-P2106
CAS No.: 1886973-05-2
Target:  

Arrestin Apelin Receptor (APJ)

Research Areas:  

Cardiovascular Disease

Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart .
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NUCC-390 dihydrochloride
NUCC-390 dihydrochloride
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6 Cited Publications
Cat. No.: HY-111793A
CAS No.: 2749281-71-6
Purity:  98.19%
Target:  

CXCR

Research Areas:  

Neurological Disease

NUCC-390 dihydrochloride is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 dihydrochloride induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046) . NUCC-390 dihydrochloride promotes nerve recovery of function after neurodegeneration in vivo .
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6
Elabela(19-32) TFA
Elabela(19-32) TFA
0 Images
6 Cited Publications
Cat. No.: HY-P2106A
Target:  

Apelin Receptor (APJ) Arrestin

Research Areas:  

Cardiovascular Disease

Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart .
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4
Pamoic acid disodium
Pamoic acid disodium
0 Images
4 Cited Publications
Cat. No.: HY-W010907
CAS No.: 6640-22-8
Target:  

GPR35 ERK

Research Areas:  

Neurological Disease

Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect .
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4
CCZ01048 TFA
CCZ01048 TFA
0 Images
4 Cited Publications
Cat. No.: HY-P2336A
Target:  

Melanocortin Receptor

Research Areas:  

Cancer

CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .
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4
VUF11207
VUF11207
0 Images
4 Cited Publications
Cat. No.: HY-100677
CAS No.: 1378524-41-4
Purity:  94.56%
Target:  

CXCR Arrestin

Research Areas:  

Cardiovascular Disease Neurological Disease Cancer

VUF11207 is a potent, selective, and orally active CXCR7/ACKR3 agonist (pKi = 8.1). VUF11207 specifically activates CXCR7/ACKR3, recruits β-arrestin, and induces receptor internalization, while downregulating the pro-inflammatory, pro-osteoclastogenic, and tumor immunosuppressive signaling mediated by the CXCL12-CXCR4 axis. VUF11207 can be used for research on glioblastoma, hypertension, and venous thrombosis .
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VUF11207 fumarate
VUF11207 fumarate
0 Images
4 Cited Publications
Cat. No.: HY-110318
CAS No.: 1785665-61-3
Purity:  98.28%
Target:  

CXCR Arrestin

Research Areas:  

Cardiovascular Disease Neurological Disease Cancer

VUF11207 fumarate is a potent, selective, and orally active CXCR7/ACKR3 agonist (pKi = 8.1). VUF11207 fumarate specifically activates CXCR7/ACKR3, recruits β-arrestin, and induces receptor internalization, while downregulating the pro-inflammatory, pro-osteoclastogenic, and tumor immunosuppressive signaling mediated by the CXCL12-CXCR4 axis. VUF11207 fumarate can be used for research on glioblastoma, hypertension, and venous thrombosis .
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3
Tephrosin
Tephrosin
0 Images
3 Cited Publications
Cat. No.: HY-N1166
CAS No.: 76-80-2
Synonyms: Deguelinol I; Hydroxydeguelin
Category:  

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