1102 Results for "

Isomers

" in MedChemExpress (MCE) Product Catalog:

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ISRIB (trans-isomer)

53 Publications Verification

Cat. No.: HY-12495

CAS No.: 1597403-47-8

Purity: 99.49%

Target:

PERK Autophagy Apoptosis

Research Areas:

Neurological Disease

ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC₅₀ of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC₅₀=5 nM).

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Glycerophosphoric acid disodium salt hydrate (α and β mixture)

18 Cited Publications

Cat. No.: HY-126304A

Purity: ≥98.0%

Target:

Biochemical Assay Reagents

Research Areas:

Others

Glycerophosphoric acid (disodium salt hydrate) (α and β mixture) is a complex contains α and β Glycerophosphoric acid isomers.

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L-Methionine

12 Cited Publications

Cat. No.: HY-N0326

CAS No.: 63-68-3

Category:

Anti-aging Endocrine diseases Amino acids Endogenous metabolite Research on Agricultural Breeding Agricultural Research Microorganisms Other Diseases Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder

Target:

Environmental Pollutants Endogenous Metabolite Apoptosis Keap1-Nrf2

L-Methionine is an L-isomer of orally active Methionine, an essential amino acid. Methionine is a strong liver antidote that acts as a liver protector. L-Methionine can inhibit cell proliferation and induce cell apoptosis. L-Methionine has antitumor and antioxidant activity .

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Bay K 8644

10 Cited Publications

Cat. No.: HY-10588

CAS No.: 71145-03-4

Purity: 99.96%

Synonyms: (±)-Bay K 8644

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease Neurological Disease

Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644 . Bay K 8644 is a L-type Ca ²⁺ channel agonist with an EC₅₀ of 17.3 nM. Bay K 8644 increases Ca ²⁺ influx through sarcolemmal Ca ²⁺ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects .

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(R)-(-)-Gossypol acetic acid

7 Cited Publications

Cat. No.: HY-15464A

CAS No.: 866541-93-7

Purity: 98.93%

Synonyms: AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid

Target:

Bcl-2 Family Autophagy

Research Areas:

Cancer

(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

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Surfactin

7 Cited Publications

Cat. No.: HY-129555

CAS No.: 252023-70-4

Purity: 98.96%

Category:

Infection Natural Products Microorganisms Disease Research Fields

Target:

Bacterial HSV Antibiotic

Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects . Surfactin also has antiviral activity against a variety of enveloped viruses .

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Citraconic acid

7 Cited Publications

Cat. No.: HY-113298

CAS No.: 498-23-7

Purity: 98.73%

Synonyms: Methylmaleic acid; Citraconate

Category:

Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:

NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)

Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .

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5(6)-Carboxyfluorescein

6 Cited Publications

Cat. No.: HY-15940

CAS No.: 72088-94-9

Synonyms: 5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed Isomers

5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo .

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Mitotane

6 Cited Publications

Cat. No.: HY-13690

CAS No.: 53-19-0

Purity: 99.92%

Synonyms: 2,4′-DDD; o,p'-DDD

Target:

Apoptosis

Research Areas:

Cancer

Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

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D-Ribose(mixture of isomers)

5 Cited Publications

Cat. No.: HY-W018772

CAS No.: 50-69-1

Category:

Microorganisms Endogenous metabolite Disease Research Fields Saccharides Cancer

Target:

Endogenous Metabolite

D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

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