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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
Jagged-1
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "Jagged-1" in MCE Product Catalog:
19
19 Publications Verification
Cat. No.: HY-P1846
CAS No.: 219127-21-6
19
19 Publications Verification
Cat. No.: HY-P1846A
11
2
Target:
Research Areas:
1
1
1 Cited Publications
Cat. No.: HY-P73258
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: JAG1; Jagged 1; Prev. JAGL1; Alagille Syndrome; Prev. AGS; Jagged-1 Protein; HJ1; CD339 Antigen; CD339; Jagged1; AHD; CMT2HH; AWS; AGS1; Protein Jagged-1; DCHE; Jagged Canonical Notch Ligand 1; Delta-Like Protein
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71633
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAG1; Jagged 1; Prev. JAGL1; Alagille Syndrome; Prev. AGS; Jagged-1 Protein; HJ1; CD339 Antigen; CD339; Jagged1; AHD; CMT2HH; AWS; AGS1; Protein Jagged-1; DCHE; Jagged Canonical Notch Ligand 1; Delta-Like Protein
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P70399
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAG1; Jagged 1; Prev. JAGL1; Alagille Syndrome; Prev. AGS; Jagged-1 Protein; HJ1; CD339 Antigen; CD339; Jagged1; AHD; CMT2HH; AWS; AGS1; Protein Jagged-1; DCHE; Jagged Canonical Notch Ligand 1; Delta-Like Protein
Species:
Human
Source:
HEK293
Cat. No.: HY-N11709
CAS No.: 220114-28-3
Cat. No.: HY-P702515
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAG1; Jagged 1; Prev. JAGL1; Alagille Syndrome; Prev. AGS; Jagged-1 Protein; HJ1; CD339 Antigen; CD339; Jagged1; AHD; CMT2HH; AWS; AGS1; Protein Jagged-1; DCHE; Jagged Canonical Notch Ligand 1; Delta-Like Protein
Species:
Rat
Source:
HEK293
Cat. No.: HY-P1849
CAS No.: 402941-23-5
Synonyms: scJag-1
Target:
Research Areas:
Cat. No.: HY-N9790
CAS No.: 79907-44-1
Target:
Cat. No.: HY-P80195
Synonyms: JAG1; AGS; AHD; AWS; HJ1; AGS1; JAGL1; AGS antibody; AHD antibody; AWS antibody; CD 339 antibody; CD339 antibody; CD339 antigen antibody; Headturner antibody; hJ1 antibody; Htu antibody; Jag 1 antibody; Jag1 antibody; JAG1_HUMAN antibody; Jagged 1 antibody; Jagged1 (Alagille syndrome) antibody; Jagged1 antibody; JAGL1 antibody; MGC104644 antibody; OTTHUMP00000030278 antibody; Protein Jagged-1 antibody; Ser 1 antibody; Ser1 antibody; Serrate 1 antibody; Slalom antibody
Cat. No.: HY-P84438
Synonyms: JAG1; AGS; AHD; AWS; HJ1; AGS1; JAGL1; AGS antibody;
AHD antibody;
AWS antibody;
CD 339 antibody;
CD339 antibody;
CD339 antigen antibody;
Headturner antibody;
hJ1 antibody;
Htu antibody;
Jag 1 antibody;
Jag1 antibody;
JAG1_HUMAN antibody;
Jagged 1 antibody;
Jagged1 (Alagille syndrome) antibody;
Jagged1 antibody;
JAGL1 antibody;
MGC104644 antibody;
OTTHUMP00000030278 antibody;
Protein Jagged-1 antibody;
Ser 1 antibody;
Ser1 antibody;
Serrate 1 antibody;
Slalom antibody
Cat. No.: HY-P84438A
Synonyms: JAG1; AGS; AHD; AWS; HJ1; AGS1; JAGL1; AGS antibody;
AHD antibody;
AWS antibody;
CD 339 antibody;
CD339 antibody;
CD339 antigen antibody;
Headturner antibody;
hJ1 antibody;
Htu antibody;
Jag 1 antibody;
Jag1 antibody;
JAG1_HUMAN antibody;
Jagged 1 antibody;
Jagged1 (Alagille syndrome) antibody;
Jagged1 antibody;
JAGL1 antibody;
MGC104644 antibody;
OTTHUMP00000030278 antibody;
Protein Jagged-1 antibody;
Ser 1 antibody;
Ser1 antibody;
Serrate 1 antibody;
Slalom antibody
Cat. No.: HY-187731
CAS No.: 685141-23-5
BXL0124 is an orally effective CD44 inhibitor and Notch signaling pathway inhibitor. BXL0124 has a vitamin D receptor-dependent mechanism and can downregulate the expression of CD44, Notch1/2/3, HES1, OCT4, LAMA5, JAG1, JAG2, NF-κB and DLL1. BXL0124 inhibits c-Myc expression and the levels of phosphorylated ERK, AKT, ErbB2, reduces the level of activated Notch1 receptor and its nuclear localization, decreases the mRNA and protein levels of Jagged-1 and Jagged-2, and inhibits the STAT3 signaling pathway by reducing the formation of the CD44-STAT3-JAK2 complex, while also inhibiting the transcriptional activity of the CD44 promoter in a p53-dependent manner. BXL0124 can induce myoepithelial differentiation and inhibit the self-renewal of cancer stem cell-like cells, cancer cell proliferation, invasion, and growth. BXL0124 can be used in research related to triple-negative breast cancer, basal-like breast cancer, ErbB2-overexpressing mammary tumorigenesis, and breast cancer [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
