17

Nitazoxanide

17 Publications Verification

Cat. No.: HY-B0217

CAS No.: 55981-09-4

Synonyms: NTZ; NSC 697855

Target:

Parasite Influenza Virus Autophagy

Research Areas:

Infection Cancer

Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC₅₀ of 2.4 μM . Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

Sulfathiazole

6 Cited Publications

Cat. No.: HY-B0507

CAS No.: 72-14-0

Target:

Environmental Pollutants Antibiotic Bacterial

Research Areas:

Endocrinology Cancer

Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

Sulfathiazole sodium

6 Cited Publications

Cat. No.: HY-B0507A

CAS No.: 144-74-1

Target:

Antibiotic Bacterial

Research Areas:

Endocrinology Cancer

Sulfathiazole sodium is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole sodium increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish. Sulfathiazole sodium is also a cathodic corrosion inhibitor. It inhibits the corrosion of copper by chloride ions through chemical and physical adsorption on the copper surface, reduces the corrosion current density and shifts the corrosion potential negatively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Octinoxate

Cat. No.: HY-B1234

CAS No.: 5466-77-3

Synonyms: Octyl methoxycinnamate

Category:

Natural Products Other Diseases Cosmetic Research Plants Other Families Extract Disease Research Fields

Target:

Environmental Pollutants Estrogen Receptor/ERR Androgen Receptor Cytochrome P450 Thyroid Hormone Receptor

Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Tolfenpyrad

Cat. No.: HY-17516

CAS No.: 129558-76-5

Target:

Environmental Pollutants Insecticide Mitochondrial Metabolism Bacterial

Research Areas:

Infection

Tolfenpyrad is an insecticide approved for marketing in Japan in 2002.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Hesperin

Cat. No.: HY-101371

CAS No.: 4430-35-7

Purity: 99.20%

Target:

Keap1-Nrf2

Research Areas:

Cancer

Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

BP13944

Cat. No.: HY-136797

CAS No.: 1622060-51-8

Target:

Dengue Virus

Research Areas:

Infection

BP13944 is a potential small molecule inhibitor discovered by high-throughput screening. It can effectively inhibit the expression of dengue virus (DENV) replicons with an EC50 value of 1.03±0.09 μM. BP13944 can inhibit the replication or viral RNA synthesis of all four serotypes of DENV, but is ineffective against Japanese encephalitis virus. BP13944 may target the DENV NS3 protease, and the E66G amino acid substitution in the NS3 protease region will cause the virus to become resistant to BP13944. BP13944 has no obvious cytotoxicity. As there is currently no effective dengue vaccine and treatment, BP13944, as an effective small molecule inhibitor, may become a potential agent for the treatment of dengue in the future.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

AH-D peptide

Cat. No.: HY-P10862

Target:

Exosomes Virus Protease

Research Areas:

Infection Cancer

AH-D peptide is a brain-penetrant antiviral agent disrupting highly curved lipid membranes. AH-D peptide exhibits broad-spectrum antiviral activity against ZIKV, Dengue virus, Chikungunya virus, yellow fever virus and Japanese encephalitis virus, with
IC₅₀
values of 11.9, 12.5, 35.7, 206 and 136 nM, respectively. AH-D peptide reduces the viral load in the brain, suppresses inflammation, protects neurons, and does not damage the blood brain barrier. AH-D peptide restores antitumor immunity by decreasing circulating PD-L1 ⁺ exosomes, reducing intratumoral immunosuppressive cells (regulatory T cells, myeloid-derived suppressor cells), and enhancing T cell function. AH-D peptide inhibits membrane-enveloped viruses and cancer cell metastasis in vivo. AH-D peptide exhibits no immunogenicity and has negligible effects on normal tissues. AH-D peptide can be used for research in Zika virus and other mosquito-borne viruses, cancer immunotherapy and metastasis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Anisatin

Cat. No.: HY-N9506

CAS No.: 5230-87-5

Category:

Terpenoids Sesquiterpenes Plants Other Families Extract

Target:

GABA Receptor

Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC₅₀ of ~1.10 μM .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Sulfathiazole-d4

Cat. No.: HY-B0507S

CAS No.: 1020719-89-4

Target:

Isotope-Labeled Compounds Antibiotic Bacterial

Research Areas:

Endocrinology Cancer

Sulfathiazole-d₄ is a deuterium labeled Sulfathiazole. Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

o,p'-DDE

Cat. No.: HY-121779

CAS No.: 3424-82-6

Synonyms: 2,4'-DDE; 2,4-Dichlorodiphenyldichloroethylene; 2,4'-DDE; o,p'-Dichlorodiphenyldichloroethylene

Target:

Insecticide

Research Areas:

Endocrinology

o,p'-DDE (2,4-Dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass, and in sediments from DDT manufacturing plants around the Huntsville Spring Branch-Indian Creek tributary system, where it is considered a persistent organic pollutant (POP). o,p'-DDE inhibits estrogen binding to the rainbow trout estrogen receptor (rtER) with an IC₅₀ value of 3.2 μM. It induces concentration-dependent estradiol secretion in co-cultures of granulosa and theca cells isolated from porcine follicles. In ovo exposure to o,p'-DDE increases follicular degeneration and reduces testis size in Japanese medaka (O. latipes).

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Sulfathiazole (100 µg/mL in acetonitrile)

Cat. No.: HY-B0507B

CAS No.: 72-14-0

Target:

Antibiotic Bacterial

Research Areas:

Endocrinology Cancer

Sulfathiazole (100 μg/mL in acetonitrile) is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole (100 μg/mL in acetonitrile) increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish. Sulfathiazole (100 μg/mL in acetonitrile) is also a cathodic corrosion inhibitor. Sulfathiazole (100 μg/mL in acetonitrile) inhibits the corrosion of copper by chloride ions through chemical and physical adsorption on the copper surface, reduces the corrosion current density and shifts the corrosion potential negatively .

Compare

loading...