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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
KCC1
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "KCC1" in MCE Product Catalog:
Target:
Research Areas:
CLP257 is a selective K +-Cl cotransporter KCC2 activator with an EC50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally [1] .
Cat. No.: HY-115606
CAS No.: 1135304-61-8
Target:
Research Areas:
ML007 is a selective antagonist targeting the neuron-specific potassium-chloride co-transporter 2 (KCC2) with an IC50 for KCC2 is 537 nM, while its inhibitory activity on KCC1 is extremely weak (IC50 > 50 μM). ML077 inhibits the chloride ion excretion function of KCC2, increasing the intracellular chloride ion concentration, thereby enhancing the depolarization mediated by chloride ion channels. ML007 can promote glucose-stimulated insulin secretion (GSIS) without relying on KATP channels. ML007 can be used to study the functions related to pain, epilepsy, and insulin secretion [1] .
Cat. No.: HY-P703216
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SLC12A4; HKCC1; Solute Carrier Family 12 Member 4; CDNA FLJ40489 Fis, Clone TESTI2044194, Highly Similar To Solute Carrier Family 12 Member 4; KCC1; Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 4, Isoform CRA_e; Solute Carrier Family
Species:
Human
Source:
HEK293
Cat. No.: HY-P703217
Synonyms: SLC12A4; HKCC1; Solute Carrier Family 12 Member 4; CDNA FLJ40489 Fis, Clone TESTI2044194, Highly Similar To Solute Carrier Family 12 Member 4; KCC1; Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 4, Isoform CRA_e; Solute Carrier Family
Species:
Human
Source:
HEK293
Cat. No.: HY-P703218
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC12A4; HKCC1; Solute Carrier Family 12 Member 4; CDNA FLJ40489 Fis, Clone TESTI2044194, Highly Similar To Solute Carrier Family 12 Member 4; KCC1; Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 4, Isoform CRA_e; Solute Carrier Family
Species:
Human
Source:
HEK293
Cat. No.: HY-RS12999
Target:
Research Areas:
SLC12A4 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC12A4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-110143R
CAS No.: 1181081-71-9
Target:
Research Areas:
CLP257 (Standard) is the analytical standard of CLP257 (HY-110143). This product is intended for research and analytical applications. CLP257 is a selective K+-Cl cotransporter KCC2 activator with an EC50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
