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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
KLHDC3
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "KLHDC3" in MCE Product Catalog:
Cat. No.: HY-RS07349
Target:
Research Areas:
KLHDC3 Human Pre-designed siRNA Set A contains three designed siRNAs for KLHDC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-177784
Research Areas:
iDeg-3 is a potent IDO1 molecular glue degrader. iDeg-3 binds to apo-IDO1 and alters its C-terminal conformation, promoting CRL2-KLHDC3 E3 ligase-mediated ubiquitination and degradation of IDO1. iDeg-3 is suitable for cancer-related research .
Cat. No.: HY-177783
Research Areas:
iDeg-1 is a potent IDO1 molecular glue degrader. iDeg-1 binds to apo-IDO1 and alters its C-terminal conformation, promoting CRL2-KLHDC3 E3 ligase-mediated ubiquitination and degradation of IDO1. iDeg-1 can be used in cancer-related research .
Cat. No.: HY-177785
Research Areas:
iDeg-6 is a molecular glue degrader that selectively targets IDO1, with a DC50 of 6.5 nM, an IC50 of 16 nM, and a Kd of 1.46 μM. iDeg-6 competes to bind the heme-binding site of apoprotein IDO1, promoting CRL2 KLHDC3-mediated polyubiquitination of IDO1 and neddylation-modification-dependent proteasomal degradation. iDeg-6 reduces kynurenine production, abrogates the non-enzymatic pro-tumor migration function of IDO1, and inhibits tumor growth in immunodeficient mice. iDeg-6 can be used in studies of cancer, infection, and neurological diseases (such as melanoma) [3] .
Cat. No.: HY-P87385
Synonyms: dJ20C7.3 antibody; hPEAS antibody; kelch domain containing 3 antibody; Kelch domain-containing protein 3 antibody; KLDC3_HUMAN antibody; KLHDC3 antibody; PEAS antibody; Protein Peas antibody; RP1-20C7.3 antibody; Testis intracellular mediator protein antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
