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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
KLK14
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "KLK14" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P71590
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KLK14; Kallikrein-Related Peptidase 14 Transcript Variant 2; Kallikrein Related Peptidase 14; Kallikrein-Related Peptidase 14 Transcript Variant 3; KLK-L6; Kallikrein 14; Kallikrein-Like Protein 6; KLKL6; Kallikrein-14; HK14
Species:
Mouse
Source:
E. coli
Cat. No.: HY-RS07378
Target:
Research Areas:
KLK14 Human Pre-designed siRNA Set A contains three designed siRNAs for KLK14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19018
Target:
Research Areas:
Klk14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Klk14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25507
Target:
Research Areas:
Klk14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Klk14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-150085
CAS No.: 2393881-77-9
Target:
Research Areas:
GSK951 is a highly potent, selective, and reversibly covalent KLK5 inhibitor, with an IC50 of approximately 250 pM and a pIC50 of 9.6 against hKLK5. It exhibits over 100-fold selectivity over KLK7, KLK14, matriptase, and elastase. GSK951 binds to the catalytic site of KLK5 via covalent interaction with the catalytic serine, with a slow dissociation rate. GSK951 improves skin barrier function, reduces transepidermal water loss, decreases the expression of proinflammatory cytokines, and inhibits the elevated KLK5 protease activity in the stratum corneum. GSK951 can be used in studies related to skin barrier dysfunction.
Cat. No.: HY-100497
CAS No.: 1087624-28-9
Target:
Research Areas:
KLK5/14-IN-1 is a selective human skin kallikrein inhibitor with IC50 values of 0.048 μM, 0.2 μM, and 0.1 μM for KLK7, KLK5, and KLK14, respectively. KLK5/14-IN-1 shows no or only low inhibitory activity against Cathepsin G, Chymotrypsin, Trypsin, and Thrombin. KLK5/14-IN-1 can be used in research related to Netherton syndrome .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
