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92 Results for "

Keap1-Nrf2

" in MedChemExpress (MCE) Product Catalog:

Products (92)

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Sulforaphane

82 Publications Verification

Cat. No.: HY-13755

CAS No.: 4478-93-7

Purity: 98.87%

Category:

Natural Products Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:

HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS)

Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

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KI696

23 Cited Publications

Cat. No.: HY-101140

CAS No.: 1799974-70-1

Purity: 98.67%

Target:

Keap1-Nrf2 Quinone Reductase

Research Areas:

Inflammation/Immunology

KI696 is a selective KEAP1/NRF2 protein-protein interaction inhibitor with a human K_d value of 1.3 nM. KI696 acts by competitively occupying the NRF2-binding pocket of the KEAP1 Kelch domain. KI696 blocks KEAP1-mediated ubiquitination and degradation of NRF2, promotes the translocation of NRF2 to the nucleus, activates the expression of downstream antioxidant genes, increases intracellular glutathione levels, and alleviates oxidative stress-induced cell damage and inflammatory cell infiltration in the lungs. KI696 reduces ozone-induced pulmonary oxidative damage and inflammatory cell accumulation in rats, and upregulates pulmonary antioxidant genes. KI696 can be used in research related to chronic obstructive pulmonary disease, oxidative stress and inflammation .

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ML334

12 Cited Publications

Cat. No.: HY-110258

CAS No.: 1432500-66-7

Purity: ≥99.0%

Synonyms: LH601A

Target:

Quinone Reductase Keap1-Nrf2

Research Areas:

Cancer

ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity .

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