44 Results for "

Keap1-Nrf2 interaction

" in MedChemExpress (MCE) Product Catalog:
Products (44)

44 Results for "Keap1-Nrf2 interaction" in MCE Product Catalog:

23
KI696
KI696
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23 Publications Verification
Cat. No.: HY-101140
CAS No.: 1799974-70-1
Purity:  98.67%
Target:  

Keap1-Nrf2 Quinone Reductase

Research Areas:  

Inflammation/Immunology

KI696 is a selective KEAP1/NRF2 protein-protein interaction inhibitor with a human Kd value of 1.3 nM. KI696 acts by competitively occupying the NRF2-binding pocket of the KEAP1 Kelch domain. KI696 blocks KEAP1-mediated ubiquitination and degradation of NRF2, promotes the translocation of NRF2 to the nucleus, activates the expression of downstream antioxidant genes, increases intracellular glutathione levels, and alleviates oxidative stress-induced cell damage and inflammatory cell infiltration in the lungs. KI696 reduces ozone-induced pulmonary oxidative damage and inflammatory cell accumulation in rats, and upregulates pulmonary antioxidant genes. KI696 can be used in research related to chronic obstructive pulmonary disease, oxidative stress and inflammation .
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12
ML334
ML334
0 Images
12 Cited Publications
Cat. No.: HY-110258
CAS No.: 1432500-66-7
Purity:  ≥99.0%
Synonyms: LH601A
Target:  

Quinone Reductase Keap1-Nrf2

Research Areas:  

Cancer

ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity .
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2
Nrf2 activator-2
Nrf2 activator-2
0 Images
2 Cited Publications
Cat. No.: HY-145879
CAS No.: 2770448-53-6
Purity:  99.20%
Target:  

Keap1-Nrf2

Research Areas:  

Cancer

Nrf2 activator-2 is an Nrf2 activator with binding affinity for Keap1, with an EC50 of 2.9 μM. Nrf2 activator-2 binds to Keap1, stabilizes the protein, inhibits the Keap1-Nrf2 interaction, and reduces the ubiquitination level of Nrf2. Nrf2 activator-2 can be used in cancer-related research .
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1
Tricetin
Tricetin
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1 Cited Publications
Cat. No.: HY-131592
CAS No.: 520-31-0
Purity:  97.73%
Category:  

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