10

L-Proline

10 Cited Publications

Cat. No.: HY-Y0252

CAS No.: 147-85-3

Category:

Microorganisms Other Diseases Amino acids Endogenous metabolite Disease Research Fields

Target:

Apoptosis Endogenous Metabolite mTOR

L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

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27

L-Arginine

27 Publications Verification

Cat. No.: HY-N0455

CAS No.: 74-79-3

Category:

Cardiovascular Disease Amino acids Endogenous metabolite Disease Research Fields Cancer

Target:

NO Synthase Endogenous Metabolite

L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

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27

L-Arginine hydrochloride

27 Publications Verification

Cat. No.: HY-N0455A

CAS No.: 1119-34-2

Synonyms: (S)-(+)-Arginine hydrochloride

Category:

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:

NO Synthase Endogenous Metabolite

L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

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8

Ipragliflozin L-Proline

8 Cited Publications

Cat. No.: HY-14894A

CAS No.: 951382-34-6

Purity: 99.94%

Target:

SGLT

Research Areas:

Metabolic Disease

Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC₅₀ of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.

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2

N-Propargylglycine

2 Cited Publications

Cat. No.: HY-142035

CAS No.: 58160-95-5

Purity: 99.70%

Target:

Mitochondrial Metabolism

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

N-Propargylglycine is a brain-penetrant and orally active PRODH inhibitor. N-Propargylglycine covalently modifies enzyme-bound FAD and active site lysine, causing enzyme structural distortion, protein decay, and irreversible inhibition of proline and 4-hydroxyproline catabolism. N-Propargylglycine induces UPRmt, upregulates mitochondrial chaperones and YME1L1, enhances mitochondrial proteostasis, blocks astrocytic L-proline consumption, and abolishes L-proline’s ATP-maintaining and viability-protective effects. N-Propargylglycine stimulates neural processes, increases brain proline, hydroxyproline, and sarcosine levels, partially normalizes Huntington’s disease whole brain transcriptomes. N-Propargylglycine reduces hyperoxaluria, prevents calcium oxalate stone formation, reduces kidney tubular damage, and restores weight and survival in Grhpr knockout mice. N-Propargylglycine can be used for the research of breast cancer, neurodegenerative disorders, Huntington’s disease, and primary hyperoxaluria type 2 .

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1

Glycyl-L-proline

1 Cited Publications

Cat. No.: HY-W016887

CAS No.: 704-15-4

Synonyms: H-Gly-Pro-OH; Gly-Pro

Category:

Alkaloids Human Gut Microbiota Metabolites Pyrrole Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Apoptosis

Glycyl-L-proline (H-Gly-Pro-OH) is a dipeptide. Glycyl-L-proline can induce MCF-7 cells apoptosis. Glycyl-L-proline can enhance the inhibitory effect of the PRODH/POX knockout on collagen and DNA biosynthesis. Glycyl-L-proline can inhibit Gly-Sar and L-proline transport. Glycyl-L-proline can be used for the researches of cancer and metabolic disease, such as breast cancer .

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1

Oxaceprol

1 Cited Publications

Cat. No.: HY-17490

CAS No.: 33996-33-7

Synonyms: N-Acetyl-L-hydroxyproline

Category:

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Amino Acid Derivatives

Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis .

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L-Proline (Standard)

Cat. No.: HY-Y0252R

CAS No.: 147-85-3

Category:

Microorganisms Amino acids Endogenous metabolite

Target:

Reference Standards Endogenous Metabolite mTOR Apoptosis

L-Proline (Standard) is the analytical standard of L-Proline. This product is intended for research and analytical applications. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

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L-Proline-13C5

Cat. No.: HY-Y0252S

CAS No.: 201740-83-2

L-Proline- ¹³C₅ is the ¹³C-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

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L-Proline-d3

Cat. No.: HY-Y0252S1

CAS No.: 65807-22-9

L-Proline-d₃ is the deuterium labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

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N-Boc-4-hydroxy-L-proline methyl ester

Cat. No.: HY-Y0755

CAS No.: 102195-79-9

Target:

ADC Linkers PROTAC Linkers

Research Areas:

Cancer

N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2

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L-Proline-d7

Cat. No.: HY-Y0252S5

CAS No.: 39063-89-3

L-Proline-d₇ is the deuterium labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

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L-Arginine (Standard)

Cat. No.: HY-N0455R

CAS No.: 74-79-3

Category:

Human Gut Microbiota Metabolites Microorganisms Amino acids Endogenous metabolite

Target:

Reference Standards NO Synthase Endogenous Metabolite

L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

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