6

MAK683

6 Publications Verification

Cat. No.: HY-103663

CAS No.: 1951408-58-4

Purity: 99.18%

Target:

Histone Methyltransferase

Research Areas:

Cancer

MAK683 is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC₅₀s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay .

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1

Medronic acid

1 Cited Publications

Cat. No.: HY-108309

CAS No.: 1984-15-2

Purity: ≥98.0%

Synonyms: Methylenediphosphonic acid

Target:

Biochemical Assay Reagents

Research Areas:

Others

Medronic acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has an affinity for the surface of hydroxyapatite crystals in the bone matrix and adheres to them. Medronic acid can be used in complex with radioisotopes in bone imaging. Due to its strong metal chelating ability, medronic acid is also used as a water treatment chemical. In addition, medronic acid is used as a solvent additive to improve peak shape and signal of metal-sensitive metabolites in LC/MS analysis .

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1

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH

1 Cited Publications

Cat. No.: HY-P0048

CAS No.: 52435-06-0

Synonyms: Surfagon

Target:

GnRH Receptor

Research Areas:

Others

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility .

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Biotin-epoxomicin

Cat. No.: HY-P11307

CAS No.: 1334608-28-4

Target:

Proteasome

Research Areas:

Cancer

Biotin-epoxomicin is a Proteasome subunit binder. Biotin-epoxomicin serves as an affinity reagent for identifying proteasomal catalytic subunits, and facilitates affinity purification of active proteasomal subunits for LC-MS identification. Biotin-epoxomicin can be used to study solid tumors derived from B16 melanoma .

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16:0 DAP

Cat. No.: HY-144022

CAS No.: 96326-74-8

Purity: ≥98.0%

Target:

Liposome

Research Areas:

Others

16:0 DAP is an ionizable cationic lipid. 1,2-dipalmitoyl-3-dimethylammonium-propane serves as a barcode lipid, enabling LC-MS quantification in ocular tissues .

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S-Phenylmercapturic acid

Cat. No.: HY-130189

CAS No.: 4775-80-8

Purity: 99.38%

Target:

Drug Metabolite

Research Areas:

Others

S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay .

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Hexadecyl-CoA

Cat. No.: HY-E70277

CAS No.: 71425-89-3

Target:

Acyltransferase Orphan Nuclear Receptor ATGL

Research Areas:

Metabolic Disease

Hexadecyl-CoA is a non-hydrolyzable thioether analog of Palmitoyl-CoA. Hexadecyl-CoA competitively inhibits the acyl-CoA thioesterase activity of HNF-4α with a K_i of 0.3 μM, and inhibits DGAT2 activity with an IC₅₀ of approximately 2 μM. Hexadecyl-CoA also inhibits ATGL activity and serves as a reference inhibitor for DGAT2 LC/MS enzyme activity assays. Hexadecyl-CoA can be used in studies related to lipid metabolism, triglyceride synthesis and lipolysis .

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2-Nitrobenzaldehyde semicarbazone-13C,15N2

Cat. No.: HY-133706S

CAS No.: 760179-80-4

2-Nitrobenzaldehyde semicarbazone- ¹³C, ¹⁵N₂ is used for analysis of semicarbazide in the LC-MS/MS method .

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S-Phenylmercapturic acid (Standard)

Cat. No.: HY-130189R

CAS No.: 4775-80-8

Target:

Drug Metabolite Reference Standards

Research Areas:

Others

S-Phenylmercapturic acid (Standard) is the analytical standard of S-Phenylmercapturic acid. This product is intended for research and analytical applications. S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay .

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MAK683 hydrochloride

Cat. No.: HY-103663A

CAS No.: 2170606-94-5

Target:

Histone Methyltransferase

Research Areas:

Cancer

MAK683 hydrochloride is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC₅₀s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay .

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γ-Linolenoyl-CoA

Cat. No.: HY-E70271

CAS No.: 27843-61-4

Synonyms: 6Z,9Z,12Z-Octadecatrienoyl-coenzyme A; γ-LinolenoyLCoenzyme A; 6Z,9Z,12Z-Octadecatrienoyl-CoA

Target:

Endogenous Metabolite

Research Areas:

Metabolic Disease

γ-Linolenoyl-CoA (C18:3(n6)-CoA) is a fatty acyl-CoA that can be used for lipidomics analysis of fatty acid-coenzyme A (FA-CoA) through LCMS/MS .

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Isoprenaline-d7 acetate

Cat. No.: HY-108353S

Isoprenalin-d7 acetate is an internal standard for the determination of isoproterenol by GC- or LC-MS .

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6-(L-1,2,3-Trihydroxybutyl)-pterin

Cat. No.: HY-W750595

CAS No.: 13392-24-0

Target:

Drug Derivative

Research Areas:

Cancer

6-(L-1,2,3-Trihydroxybutyl)-pterin is a derivative of L-biopterin (HY-102015) and is the oxidized form of tetrahydro-L-biopterin (BH4) as well as D-biopterin. Co-ingestion of 6-(L-1,2,3-Trihydroxybutyl)-pterin (0.5%) with the carcinogen 4-dimethylaminoazobenzene reduces the incidence of 4-dimethylaminoazobenzene-induced liver tumors in rats. 6-(L-1,2,3-Trihydroxybutyl)-pterin has been used as an internal standard for the LC-MS quantification of biopterin and neopterin in rat plasma.

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MAK683 (Standard)

Cat. No.: HY-103663R

CAS No.: 1951408-58-4

Target:

Reference Standards Histone Methyltransferase

Research Areas:

Cancer

MAK683 (Standard) is the analytical standard of MAK683 (HY-103663). This product is intended for research and analytical applications. MAK683 is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC₅₀s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay .

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Trypsin-N (MS grade)

Cat. No.: HY-E71359

Target:

Ser/Thr Protease Biochemical Assay Reagents

Research Areas:

Others

Trypsin-N is a mass spectrometry-grade protease specifically designed for mass spectrometry-based enzymatic digestion of denatured proteins, suitable for LC-MS/MS analysis. It is a key tool enzyme for proteomics research.

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