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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
LC3 puncta
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "LC3 puncta" in MCE Product Catalog:
1
1 Cited Publications
Autophagy inducer 3 has autophagy induced activity. Autophagy inducer 3 possesses robust autophagic cell death in diverse cancer cells sparing normal counterpart. Autophagy inducer 3 induces lethal autophagy by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins .
ATG7-IN-3 (Compound 18) is a potent ATG7 inhibitor with an IC50 of 0.048 μM. ATG7-IN-3 inhibits Autophagy. ATG7-IN-3 inhibits the formation of LC3B puncta. ATG7-IN-3 can be used in the researches of glioma and colon cancer .
Cat. No.: HY-161739
CAS No.: 2409960-03-6
YOK-1304 is a p62/Sequestosome-1/SQSTM1 ligand that binds to the p62-ZZ domain. YOK-1304 promotes p62 self-oligomerization and LC3 interaction to facilitate autophagic targeting and p62-dependent selective autophagy. YOK-1304 enhances autophagic flux, induces LC3 puncta formation and p62-LC3 colocalization, and serves as an autophagy-targeting ligand (ATL) that can be linked to target-binding ligands to generate AUTOTAC degraders. YOK-1304 is used in research on cervical cancer and pancreatic cancer .
Cat. No.: HY-170998
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ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent ATG16L1 stabilizer that promotes cellular Autophagy. ATG16L1 stabilizer-1 inhibits ATG16L1 with an EC50 of 12.1 μM in the presence or absence of FKBP12. ATG16L1 stabilizer-1 alone induces GFP-LC3 puncta formation to a small extent with an EC50 of 12.0 μM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
