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32 Results for "

LTA4

" in MedChemExpress (MCE) Product Catalog:

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Bufexamac

2 Cited Publications

Cat. No.: HY-B0494

CAS No.: 2438-72-4

Synonyms: Bufexamic acid

Target:

HDAC Aminopeptidase

Research Areas:

Inflammation/Immunology Cancer

Bufexamac is a selective Ⅱb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, with K_ds of 0.53 µM and 0.22 µM for HDAC6 and HDAC10. Bufexamac is a nonsteroida anti-inflammatory drug .

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SC-57461A

2 Cited Publications

Cat. No.: HY-103226

CAS No.: 423169-68-0

Purity: 99.93%

Target:

Aminopeptidase

Research Areas:

Inflammation/Immunology

SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC₅₀s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively .

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LYS006

Cat. No.: HY-137298

CAS No.: 1799681-85-8

Purity: 98.61%

Synonyms: LTA4H-IN-1

Target:

Aminopeptidase

Research Areas:

Inflammation/Immunology

LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC₅₀ of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders .

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Methyl arachidate

Cat. No.: HY-W004291

CAS No.: 1120-28-1

Synonyms: Methyl icosanoate

Category:

Natural Products Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:

Aminopeptidase

Methyl arachidate (Methyl icosanoate) is a component of lipid mixtures. Methyl arachidate can be isolated from flowering plants. Methyl arachidate inhibits LTA4H. Methyl arachidate shows no antifeedant activity against Leptinotarsa decemlineata .

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Leukotriene A4 methyl ester

Cat. No.: HY-112621

CAS No.: 73466-12-3

Synonyms: LTA4 methyl ester

Target:

Biochemical Assay Reagents

Research Areas:

Inflammation/Immunology

Leukotriene A4 methyl ester (LTA4 methyl ester) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

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Leukotriene C4-d5

Cat. No.: HY-113446S

CAS No.: 1441421-73-3

Purity: 97.9%

Leukotriene C4-d₅ is the deuterium labeled Leukotriene C4. Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4.

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4-MDM

Cat. No.: HY-W097753

CAS No.: 834-14-0

Synonyms: 4-Methoxydiphenylmethane

Target:

Aminopeptidase

Research Areas:

Others

4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A₄ Hydrolase (LTA₄H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by LTA₄H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA₄H. 4-MDM can be used for research on lung diseases .

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