40 Results for "

Learning and memory impairments

" in MedChemExpress (MCE) Product Catalog:
Products (40)

40 Results for "Learning and memory impairments" in MCE Product Catalog:

55
Bucladesine sodium
Bucladesine sodium
0 Images
55 Publications Verification
Cat. No.: HY-B0764
CAS No.: 16980-89-5
Synonyms: Dibutyryl cAMP sodium; DBcAMP sodium
Target:  

PKA Reactive Oxygen Species (ROS) Apoptosis

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Bucladesine (Dibutyryl cAMP; DBcAMP) sodium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .
loading...
    loading...
View All Sizes
55
Bucladesine hemicalcium
Bucladesine hemicalcium
0 Images
55 Publications Verification
Cat. No.: HY-B0764A
CAS No.: 938448-87-4
Synonyms: Dibutyryl cAMP hemicalcium; DBcAMP hemicalcium
Target:  

PKA Apoptosis Reactive Oxygen Species (ROS)

Research Areas:  

Neurological Disease Cancer

Bucladesine (Dibutyryl cAMP; DBcAMP) hemicalcium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .
loading...
    loading...
View All Sizes
20
Rolipram
Rolipram
0 Images
20 Cited Publications
Cat. No.: HY-16900
CAS No.: 61413-54-5
Synonyms: (R,S)-Rolipram; (±)-Rolipram; ZK 62711
Target:  

Bacterial HIV Phosphodiesterase (PDE) Epigenetic Reader Domain Amyloid-β

Research Areas:  

Infection Neurological Disease Cancer

Rolipram is a PDE4 inhibitor, with blood-brain barrier permeability, that reverses β-amyloid-induced learning and memory impairment in rats. Rolipram elevates intracellular cAMP and clevels and regulates the cAMP/CREB signaling pathway, thereby alleviating neuroinflammation and apoptotic responses. Rolipram promotes neuronal differentiation of human bone marrow mesenchymal stem cells and inhibits Methamphetamine- and morphine-induced hyperlocomotion in mice. Rolipram also reduces the viability of glioblastoma stem-like cells and enhances Bevacizumab (HY-P9906)-induced cell death. Rolipram inhibits the expression of proinflammatory cytokines and enhances central noradrenergic transmission. Rolipram is mainly used in studies related to various central nervous system diseases including Alzheimer's disease, major depressive disorder, glioblastoma multiforme, and multiple sclerosis .
loading...
    loading...
View All Sizes
5
Baimaside
Baimaside
0 Images
5 Cited Publications
Cat. No.: HY-N2183
CAS No.: 18609-17-1
Synonyms: Quercetin 3-O-sophoroside
Category:  

Flavonols Flavonoids Other Diseases Phenols Polyphenols Plants 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.