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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
Lin28A
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "Lin28A" in MCE Product Catalog:
2
2 Cited Publications
Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction.
Target:
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Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells .
Cat. No.: HY-168437
LIN28-IN-2 is a Lin28 inhibitor with activity against Lin28a, Lin28b, and their zinc knuckle domain. LIN28-IN-2 blocks Lin28-RNA substrate binding, perturbs zinc knuckle domain conformation. LIN28-IN-2 inhibits cancer cell proliferation, spheroid growth, and induces G2/M phase arrest. LIN28-IN-2 suppresses cancer stem cell phenotypes, Lin28-mediated stress granule formation, let-7 target genes, cancer stem cell biomarkers, and neuroendocrine biomarkers expression in cancer cells. LIN28-IN-2 can be used for the research of cancer .
Cat. No.: HY-RS07671
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LIN28A Human Pre-designed siRNA Set A contains three designed siRNAs for LIN28A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-174590
Human Lin-28 homolog A (LIN28A) mRNA encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. LIN28A functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.
Cat. No.: HY-177782
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SB1349 is a potent Lin28 molecular glues degrader, with DC50 values of 1.594 µM and 0.777 µM for Lin28A and Lin28B, respectively. SB1349 induces proteasome-dependent degradation by directly binding and recruiting the E3 ubiquitin ligase RNF126. SB1349 can be used for the study of neuroblastoma .
Cat. No.: HY-177731
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MG-Lin1 is a Lin28/Lin28A molecular glue degrader with a DC50 of approximately 0.7 μM. It induces Lin28 degradation via the ubiquitin-proteasome pathway by forming a ternary complex, thereby upregulating the levels of let-7 miRNA and reducing the expression of its downstream oncogenic targets KRAS and PDK1, and inhibiting cancer cell migration. MG-Lin1 can be used in studies of ovarian cancer and choriocarcinoma .
Cat. No.: HY-P704522
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Lin28A; Zinc Finger CCHC Domain-Containing Protein 1; Prev. Lin28; FLJ12457; ZCCHC1; Lin-28A; CSDD1; Zinc Finger, CCHC Domain Containing 1; Lin-28 Homolog A; Lin-28 Homolog (C. Elegans); Lin-28; RNA-Binding Protein Lin-28; Lin-28 RNA Binding Posttranscrip
Species:
Human
Source:
E. coli
Cat. No.: HY-168346
CAS No.: 2702331-04-0
Research Areas:
TS-002455 (Example 668) is an inhibitor for Lin28a-dep Z11 with an IC50 < 1 μM. TS-002455 is the enantiomer of TS-002266 (HY-169091) .
Cat. No.: HY-P80744A
Synonyms: CSDD1; FLJ12457; Lin 28; Lin-28A; Lin28; Lin28A; LN28A_HUMAN; Protein Lin-28 homolog A; ZCCHC1; Zinc finger CCHC domain-containing protein 1.
Cat. No.: HY-100692R
CAS No.: 2024548-03-4
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Lin28-let-7a antagonist 1 (Standard) is the analytical standard of Lin28-let-7a antagonist 1 (HY-100692). This product is intended for research and analytical applications. Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
