Target:

Research Areas:

Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNP) for mRNA delivery in vivo. LNPs containing Lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNP containing Lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 (PD-1) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3 ⁺CD8 ⁺ central and CD3 ⁺CD8 ⁺ effector memory T cells and decrease the percentage of CD3 ⁺ T cells expressing Pd-1, in the spleen in a CT26 murine EBV-infected colon cancer model .

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2

C2 Ceramide

2 Cited Publications

Cat. No.: HY-101180

CAS No.: 3102-57-6

Purity: 99.85%

Synonyms: Ceramide 2

Target:

Phosphatase Mitochondrial Metabolism Apoptosis Autophagy

Research Areas:

Metabolic Disease Endocrinology

C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss .

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1

DPPC-13C2

1 Cited Publications

Cat. No.: HY-109506S9

CAS No.: 65277-91-0

Purity: ≥95.0%

Synonyms: 129Y83-¹³C₂

DPPC-13C2 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

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Acetyl coenzyme A-13C2 lithium

Cat. No.: HY-114293S

Purity: 97.40%

Synonyms: Acetyl-CoA-¹³C₂ lithium

Target:

Isotope-Labeled Compounds Endogenous Metabolite Autophagy Oxidative Phosphorylation

Research Areas:

Metabolic Disease

Acetyl coenzyme A- ¹³C₂ lithium is the ¹³C-labeled Acetyl coenzyme A (HY-114293). Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis .

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DLin-M-K-DMA

Cat. No.: HY-154803

CAS No.: 1221271-55-1

Purity: ≥98.0%

Synonyms: DLin-M-C2-DMA

Target:

Liposome

Research Areas:

Others

DLin-M-K-DMA (DLin-M-C2-DMA) is a cationic lipid that can be used in the construction of biological delivery vectors .

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ssPalmE-P4-C2

Cat. No.: HY-176518

CAS No.: 2247153-41-7

Target:

Liposome Ser/Thr Protease

Research Areas:

Infection Neurological Disease Metabolic Disease

ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED₅₀ of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research .

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