Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
95 Results for "
Lipid-lowering
" in MedChemExpress (MCE) Product Catalog:
Products (95)
95 Results for "Lipid-lowering" in MCE Product Catalog:
13
Research Areas:
Linerixibat (GSK2330672) is a highly potent, nonabsorbable and orally active apical sodium-dependent bile acid transporter (ASBT) inhibitor with an IC50 of 42 nM human ASBT. Linerixibat can be used as lipid-lowering agent. Linerixibat has the potential for type 2 diabetes and Primary Biliary Cholangitis treatment .
11
11 Cited Publications
Synonyms: Chuanxiongzine; Tetramethylpyrazine
11
11 Cited Publications
Cat. No.: HY-N0935
CAS No.: 76494-51-4
Synonyms: Chuanxiongzine hydrochloride; Tetramethylpyrazine hydrochloride
10
9
9 Cited Publications
Cat. No.: HY-N6653
CAS No.: 37339-90-5
Category:
Plant Polysaccharides Agaricaceae Extract Lentinus edodes (Berk. ) Sing Extract Disease Research Fields Saccharides Cancer
Target:
8
8 Cited Publications
Synonyms: AEGR-733 mesylate; BMS-201038 mesylate
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Lomitapide (AEGR-733; BMS-201038) mesylate is an orally active microsomal triglyceride transfer protein (MTP) inhibitor and a selective mTORC1 inhibitor with lipid-lowering activity and BBB permeability. Lomitapide mesylate significantly reduces plasma LDL levels by blocking the assembly and secretion of very-low-density lipoprotein (VLDL). Lomitapide mesylate inhibits mTORC1 in an ATP-dependent manner, thereby inducing AMPK-independent autophagic cell death and suppressing cancer cell growth and apoptosis. Lomitapide mesylate also enhances tumor infiltration of CD8 + T cells. In addition, Lomitapide mesylate inhibits HDAC, improves endothelial function, effectively alleviates vascular inflammation and oxidative stress, and exerts neuroprotective effects in a cerebral ischemia/reperfusion injury model. Lomitapide mesylate can be used in research on related diseases such as colorectal cancer, breast cancer, melanoma, ischemic stroke, and familial hypercholesterolemia .
7
Target:
Research Areas:
Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.
6
6 Cited Publications
Target:
Research Areas:
YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .
5
Target:
3
3 Cited Publications
Cat. No.: HY-N0458
CAS No.: 42719-32-4
Category:
Ilex rotunda Thunb. Extract Triterpenes Plant Terpenoids Aquifoliaceae Extract Metabolic Disease Disease Research Fields
Target:
2
2 Cited Publications
Cat. No.: HY-W001171
CAS No.: 548-93-6
Category:
Human Gut Microbiota Metabolites Monophenols Ketones, Aldehydes, Acids Other Diseases Phenols Microorganism Endogenous metabolite Disease Research Fields
Target:
2
2 Cited Publications
Target:
Research Areas:
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .
2
Target:
1
1 Cited Publications
Cat. No.: HY-N0807
CAS No.: 17388-39-5
Category:
Plant Monophenols Enicostemma littorale Blume Extract Metabolic Disease Phenols Other Families Extract Disease Research Fields Cancer
Target:
1
Category:
Alkaloids Plant Other Alkaloids Isatis tinctoria L. Extract Cruciferae Extract Disease Research Fields Brassicaceae Extract Cancer
Target:
1
1 Cited Publications
Research Areas:
LUF6283 is a potent and orally active HCA(2) partial agonist, with a Ki of 0.55 µM. LUF6283 can achieve the beneficial lipid lowering effect of niacin without producing the unwanted cutaneous flushing side effect .
1
1 Cited Publications
Target:
Research Areas:
GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity .
Cat. No.: HY-W015924
CAS No.: 594-61-6
Target:
Cat. No.: HY-W006405
CAS No.: 574-12-9
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Glycine max (L.) merr Extract Other Diseases Disease Research Fields Isoflavones
Target:
Target:
Research Areas:
Hepronicate, a nicotinic acid derivative, is a peripheral vasodilator with blood lipid lowering action. Hepronicate works by improving peripheral circulatory disturbances .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
