730 Results for "

M receptor

" in MedChemExpress (MCE) Product Catalog:
Products (730)

730 Results for "M receptor" in MCE Product Catalog:

181
Pexidartinib hydrochloride
Pexidartinib hydrochloride
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181 Publications Verification
Cat. No.: HY-16749A
CAS No.: 2040295-03-0
Synonyms: PLX-3397 hydrochloride
Target:  

c-Fms c-Kit Apoptosis

Research Areas:  

Cancer

Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity .
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181
Pexidartinib
Pexidartinib
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181 Publications Verification
Cat. No.: HY-16749
CAS No.: 1029044-16-3
Synonyms: PLX-3397
Target:  

c-Fms c-Kit Apoptosis

Research Areas:  

Cancer

Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity. Pexidartinib has limited permeability to the blood-brain barrier, primarily through ABCB1 .
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179
Clozapine N-oxide
Clozapine N-oxide
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179 Cited Publications
Cat. No.: HY-17366
CAS No.: 34233-69-7
Target:  

Drug Metabolite mAChR Dopamine Receptor

Research Areas:  

Neurological Disease

Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
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179
Clozapine N-oxide dihydrochloride
Clozapine N-oxide dihydrochloride
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179 Cited Publications
Cat. No.: HY-17366A
CAS No.: 2250025-93-3
Target:  

mAChR Dopamine Receptor Drug Metabolite

Research Areas:  

Neurological Disease

Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
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161
Chlorpromazine
Chlorpromazine
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161 Cited Publications
Cat. No.: HY-12708
CAS No.: 50-53-3
Purity:  99.75%
Target:  

Dopamine Receptor Cytochrome P450 Autophagy 5-HT Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis .
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161
Chlorpromazine hydrochloride
Chlorpromazine hydrochloride
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161 Cited Publications
Cat. No.: HY-B0407A
CAS No.: 69-09-0
Target:  

Dopamine Receptor Autophagy Cytochrome P450 5-HT Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .
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72
Lactic acid sodium (60% w/w in water)
Lactic acid sodium (60% w/w in water)
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72 Cited Publications
Cat. No.: HY-B2227B
CAS No.: 72-17-3
Synonyms: DL-Lactic acid sodium; E-270 sodium
Target:  

Environmental Pollutants Endogenous Metabolite Bacterial Hydroxycarboxylic Acid Receptor (HCAR)

Research Areas:  

Infection Metabolic Disease Inflammation/Immunology Cancer

Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .
This product has a content (w/w) of 60%, and 1 mL of the system contains 798 mg of Lactic acid sodium, i.e., a concentration of 798 mg/mL (i.e., 7.12 M).
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48
Pilocarpine Hydrochloride
Pilocarpine Hydrochloride
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48 Cited Publications
Cat. No.: HY-B0726
CAS No.: 54-71-7
Category:  

Alkaloids Other Alkaloids Plants Other Families Extract

Target:  

mAChR

Pilocarpine Hydrochloride is an orally active, selective M3 muscarinic acetylcholine receptor agonist. Pilocarpine Hydrochloride can induce seizures and is used in research on conditions such as epilepsy, dry mouth (xerostomia), and elevated intraocular pressure .
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48
Pilocarpine
Pilocarpine
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48 Cited Publications
Cat. No.: HY-B0726A
CAS No.: 92-13-7
Target:  

mAChR

Research Areas:  

Neurological Disease Cancer

Pilocarpine is an orally active, selective M3 muscarinic acetylcholine receptor agonist. Pilocarpine can induce seizures. Pilocarpine is used in research on conditions such as epilepsy, dry mouth (xerostomia), and elevated intraocular pressure .
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48
Pilocarpine nitrate
Pilocarpine nitrate
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48 Cited Publications
Cat. No.: HY-B1006
CAS No.: 148-72-1
Category:  

Alkaloids Other Alkaloids Plants Other Families Extract

Target:  

mAChR

Pilocarpine nitrate is an orally active, selective M3 muscarinic acetylcholine receptor agonist. Pilocarpine nitrate can induce seizures and is used in research on conditions such as epilepsy, dry mouth (xerostomia), and elevated intraocular pressure .
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30
Hesperetin
Hesperetin
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30 Cited Publications
Cat. No.: HY-N0168
CAS No.: 520-33-2
Category:  

Flavonoids Neurological Disease Sunscreen Flavonones Cosmetic Research Plants Other Families Extract Disease Research Fields Cancer

Target:  

p38 MAPK Autophagy Apoptosis Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family

Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .
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29
Atropine
Atropine
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29 Cited Publications
Cat. No.: HY-B1205
CAS No.: 51-55-8
Synonyms: Tropine tropate; DL-Hyoscyamine
Category:  

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