52 Results for "

M2 channel

" in MedChemExpress (MCE) Product Catalog:
Products (52)

52 Results for "M2 channel" in MCE Product Catalog:

161
Chlorpromazine
Chlorpromazine
0 Images
161 Publications Verification
Cat. No.: HY-12708
CAS No.: 50-53-3
Purity:  99.75%
Target:  

Dopamine Receptor Cytochrome P450 Autophagy 5-HT Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis .
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161
Chlorpromazine hydrochloride
Chlorpromazine hydrochloride
0 Images
161 Publications Verification
Cat. No.: HY-B0407A
CAS No.: 69-09-0
Target:  

Dopamine Receptor Autophagy Cytochrome P450 5-HT Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .
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76
Shikonin
Shikonin
0 Images
76 Cited Publications
Cat. No.: HY-N0822
CAS No.: 517-89-5
Synonyms: C.I. 75535; Isoarnebin 4
Category:  

Quinones Boraginaceae Extract Plants 500 - Internal Server Error | MedChemExpress

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