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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
MAP2K4
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "MAP2K4" in MCE Product Catalog:
Cat. No.: HY-159190
CAS No.: 2409140-12-9
Target:
Research Areas:
HRX-0233 is an orally potent MAP2K4 inhibitor. HRX-0233 inhibits the MAP2K4-JNK-JUN signaling pathway, blocks the feedback activation of receptor tyrosine kinases, and sustains the inhibitory effect on KRAS signaling. HRX-0233 exerts synergistic inhibition on the mTORC1 and MAPK pathways. When combined with Ipatasertib (HY-15186) or Sotorasib (HY-114277), it produces synergistic antiproliferative, pro-apoptotic (apoptosis) and antitumor effects, and shows good tolerability in mouse models. HRX-0233 can be used in CRISPR knockout screens to identify vulnerability-related genes. HRX-0233 is applicable to research related to prostate cancer, non-small cell lung cancer and colorectal cancer .
Cat. No.: HY-RS08040
Target:
Research Areas:
MAP2K4 Human Pre-designed siRNA Set A contains three designed siRNAs for MAP2K4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16235
Target:
Research Areas:
Map2k4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Map2k4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-189874
GMC10 is a selective MAP2K7 inhibitor with an IC50 of <1 nM for MAP2K7 and an IC50 of 340 nM for MAP2K4. GMC10 inhibits JNK pathway signaling. GMC10 enhances MRTX1133 (HY-134813)-induced Apoptosis. GMC10 can be used for research on pancreatic ductal adenocarcinoma .
Cat. No.: HY-P700589
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAP2K4; MAPKK4; Prev. SERK1; C-Jun NH2-Terminal Kinase Kinase 1; PRKMK4; C-Jun N-Terminal Kinase Kinase 1; SAPKK1; JNK-Activating Kinase 1; JNKK1; MAP Kinase Kinase 4; MEK4; MAPK/ERK Kinase 4; MKK4; MAPKK 4; SKK1; SAPKK-1; JNKK; MEK 4; SEK1; JNK-Activated
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P706077
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAP2K4; MAPKK4; Prev. SERK1; C-Jun NH2-Terminal Kinase Kinase 1; PRKMK4; C-Jun N-Terminal Kinase Kinase 1; SAPKK1; JNK-Activating Kinase 1; JNKK1; MAP Kinase Kinase 4; MEK4; MAPK/ERK Kinase 4; MKK4; MAPKK 4; SKK1; SAPKK-1; JNKK; MEK 4; SEK1; JNK-Activated Kinase 1; Stress-Activated Protein Kinase Kinase 1; SAPK Kinase 1; SAPK/ERK Kinase 1; Mitogen-Activated Protein Kinase Kinase 4; Dual Specificity Mitogen-Activated Protein Kinase Kinase 4
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P704064
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAP2K4; MAPKK4; Prev. SERK1; C-Jun NH2-Terminal Kinase Kinase 1; PRKMK4; C-Jun N-Terminal Kinase Kinase 1; SAPKK1; JNK-Activating Kinase 1; JNKK1; MAP Kinase Kinase 4; MEK4; MAPK/ERK Kinase 4; MKK4; MAPKK 4; SKK1; SAPKK-1; JNKK; MEK 4; SEK1; JNK-Activated
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P85275
Synonyms: MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro
Cat. No.: HY-P86344
Synonyms: MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro
Cat. No.: HY-P85275A
Synonyms: MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro
Cat. No.: HY-P80834
Synonyms: MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
