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560 Results for "

MCF 7

" in MedChemExpress (MCE) Product Catalog:

Products (560)

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149

Fulvestrant

149 Publications Verification

Cat. No.: HY-13636

CAS No.: 129453-61-8

Purity: 99.92%

Synonyms: ICI 182780; ZD 9238; ZM 182780

Target:

Estrogen Receptor/ERR Autophagy Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC₅₀ of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC₅₀ of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy .

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CTB

14 Cited Publications

Cat. No.: HY-134964

CAS No.: 451491-47-7

Purity: 99.93%

Target:

Histone Acetyltransferase Apoptosis

Research Areas:

Neurological Disease Cancer

CTB is a potent p300 histone acetyltransferase activator . CTB can effectively induce apoptosis in MCF-7 cells .

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PX-12

14 Cited Publications

Cat. No.: HY-13734

CAS No.: 141400-58-0

Purity: 99.87%

Synonyms: IV-2

Target:

Apoptosis

Research Areas:

Cancer

PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC₅₀ values of 1.9 and 2.9 μM, respectively.

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FDI-6

8 Cited Publications

Cat. No.: HY-112721

CAS No.: 313380-27-7

Purity: 99.65%

Target:

FOXM1 DNA/RNA Synthesis

Research Areas:

Cancer

FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation.

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Lomeguatrib

6 Cited Publications

Cat. No.: HY-13668

CAS No.: 192441-08-0

Purity: 98.83%

Synonyms: PaTrin-2

Target:

DNA Methyltransferase

Research Areas:

Cancer

Lomeguatrib is a O ⁶-methylguanine-DNA methyltransferase (MGMT) inhibitor, with IC₅₀s of 9 nM in cell-free assay and ～6?nM in MCF-7 cells.

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Danazol

4 Cited Publications

Cat. No.: HY-B1029

CAS No.: 17230-88-5

Target:

PKC Apoptosis Tyrosinase

Research Areas:

Endocrinology Cancer

Danazol inhibits the proliferation of cancer cell MDA-MB-231 and MCF-7 with IC₅₀ of 65 µg/mL and 31 µg/mL. Danazol arrests the cell cycle at G1 phase, induces apoptosis in MDA-MB-231 through PKCα signaling pathway .

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