111 Results for "

MCP-1

" in MedChemExpress (MCE) Product Catalog:
Products (111)

111 Results for "MCP-1" in MCE Product Catalog:

44
Bardoxolone methyl
Bardoxolone methyl
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44 Publications Verification
Cat. No.: HY-13324
CAS No.: 218600-53-4
Purity:  98.92%
Synonyms: RTA 402; NSC 713200; CDDO Methyl ester
Target:  

Keap1-Nrf2 SARS-CoV Virus Protease

Research Areas:  

Infection Neurological Disease Inflammation/Immunology

Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC50 value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) [1] .
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32
Bindarit
Bindarit
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32 Cited Publications
Cat. No.: HY-B0498
CAS No.: 130641-38-2
Synonyms: AF2838
Category:  

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